| Gene Symbol | HCN1PROTEIN |
| Protein Type | Channel |
| Target Class | Ion Channel |
| Function | is a voltage-gated ion channel that generates the hyperpolarization-activated current (I_h), also known as the "pacemaker current. |
| Mechanism of Action | HCN1 encodes a hyperpolarization-activated cyclic nucleotide-gated channel critical for neuronal pacemaking and synaptic integration, with dysregulation linked to hyperexcitability disorders and potential neurodegeneration mechanisms. Specifically, HCN1 channel dysfunction can alter neuronal excitability, synaptic plasticity, and potentially contribute to neuronal death or dysfunction in conditions like epilepsy and neurodegenerative diseases. |
| Subcellular Localization | Isoform-specific trafficking to different neuronal compartments |
| Druggability | Medium (0.51) |
| Clinical Stage | Approved |
| Molecular Weight | 100 kDa |
| Amino Acids | 910 aa |
| GeneCards | HCN1PROTEIN |
| Human Protein Atlas | HCN1PROTEIN |
| S5-S6 (Amino acids 300-450) | The pore domain forms the ion conduction pathway. The P-loop between S5 and S6 contains the selectivity filter that determines ion selectivity. |
| Biophysical properties | Different isoforms have distinct activation and deactivation kinetics |
| Modulation | Heteromeric channels have intermediate pharmacological properties |
| Associated Diseases | Absence Seizures, AD, ALI, Als, Alzheimer's disease |
| Known Drugs/Compounds | ketamine, propofol, Propofol, Zd7288 |
| Interactions | AND, App, BDNF, C1Q, EPILEPSY, Fus |
| SciDEX Target | View Target Profile (8 clinical trials) |
| SciDEX Hypotheses | HCN1-Mediated Resonance Frequency Stabilization Th HCN1-Selective Blockade Normalizes Thalamic Reboun |
| KG Connections | 324 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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