| Gene Symbol | GAB2 |
| Chromosome | 11q14.1 |
| Function | PI3K/AKT pathway amplification: Upon tyrosine phosphorylation, GAB2 recruits the p85 regulatory subunit of PI3K, leading to robust AKT activation. |
| Primary Expression | Brain (hippocampus, cortex), hematopoietic cells, mast cells |
| Molecular Weight | 74 kDa |
| Amino Acids | 676 aa |
| Exons | 25 |
| Pathways | PI3K, MAPK signaling |
| UniProt ID | Q9UQC2 |
| NCBI Gene ID | 9846 |
| Ensembl ID | ENSG00000033327 |
| OMIM | 606203 |
| GeneCards | GAB2 |
| Human Protein Atlas | GAB2 |
| Tyrosine phosphorylation | Multiple sites phosphorylated by receptor tyrosine kinases (EGFR, c-MET, c-Kit) and non-receptor kinases (Src family) |
| Associated Diseases | Alzheimer |
| Interactions | ABCA7, APOE, BIN1, CD2AP, CLU, CR1 |
| KG Connections | 39 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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