| Gene Symbol | DAT |
| Aliases | DATPROTEIN |
| Protein Family | Na+/Cl- dependent neurotransmitter transporter (SLC6) |
| Function | Dat Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes. |
| Subcellular Localization | ** | Plasma membrane, presynaptic terminals | |
| Molecular Weight | ~79 kDa (glycosylated) |
| Pathways | dopamine neurotransmission, membrane diffusion, vesicular traffic |
| UniProt ID | Q01959 |
| GeneCards | DAT |
| Human Protein Atlas | DAT |
| 12 Transmembrane Domains | Characteristic of neurotransmitter transporters |
| Intracellular N- and C-termini | Important for regulation |
| Glycosylated Extracellular Loops | 2-4 glycosylation sites |
| Substrate Binding Site | Central to the transport mechanism |
| Dopamine Reuptake | Primary mechanism for synaptic dopamine clearance |
| Associated Diseases | ALS, Alzheimer's disease, Levodopa-Induced Motor Complications, Parkinson, Parkinson's disease |
| Known Drugs/Compounds | curcumin, levodopa |
| Interactions | AND, ANKK1, COMT, DRD2, EN1, EN2 |
| KG Connections | 69 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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