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protein 1,258 words KG: DAP12PROTEIN
Contents

DAP12 Protein

🔬 Protein Info
Gene SymbolDAP12
AliasesTYROBP
Chromosome19q13.12.
Primary ExpressionHippocampus
Molecular Weight12 kDa
PathwaysPI3K
GeneCardsDAP12
Human Protein AtlasDAP12
Associated DiseasesALS, Alzheimer, Alzheimer'S Disease, disease, Nasu-Hakola Disease, neurodegeneration
InteractionsAKT, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, APOE, APOPTOSIS
KG Connections196 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (19)

Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.72TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69TREM2-mediated microglial tau clearance enhancement
Score: 0.62Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79Competitive APOE4 Domain Stabilization Peptides
Score: 0.78APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76APOE Isoform Expression Across Glial Subtypes
Score: 0.74APOE4-Selective Lipid Nanoemulsion Therapy
Score: 0.74APOE-TREM2 Interaction Modulation
Score: 0.74Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72APOE Isoform Conversion Therapy
Score: 0.72Membrane Cholesterol Gradient Modulators
Score: 0.71Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62TREM2-Mediated Selective Aggregate Clearance Pathway
Score: 0.58TREM2-Dependent Microglial Senescence Transition
Score: 0.54

Related Analyses (8)

Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archivedSynaptic pruning by microglia in early AD
neurodegeneration · archivedMitochondrial transfer between astrocytes and neurons
neurodegeneration · archivedTDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archivedCircuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

Microglial TREM2 Agonist In Vivo Efficacy
validation · proposed · Score: 0.45

See Also (15)

Neurodegeneration
disease · KG edge: implicated_inAntibody Therapy in Neurodegeneration
mechanism · Pages share 3 hypothesesAxon Guidance Pathways in Neurodegeneration
mechanism · Pages share 3 hypothesesConvergent Pathways in Neurodegeneration
mechanism · Pages share 3 hypothesesCOVID-19 Neurodegeneration Mechanism
mechanism · Pages share 3 hypotheses

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