| Gene Symbol | CYCSPROTEIN |
| Function | is a mobile electron shuttle in the mitochondrial intermembrane space |
| Subcellular Localization | </span><span class="infobox-value">Mitochondrial intermembrane space</span></div> |
| Amino Acids | 104 aa |
| GeneCards | CYCSPROTEIN |
| Human Protein Atlas | CYCSPROTEIN |
| Heme attachment | The iron-porphyrin ring is covalently linked via thioether bonds to Cys14 and Cys17 through a conserved CXXCH motif. His18 and Met80 serve as axial ligands to the central iron atom. |
| Redox-active iron | Cycles between Fe²⁺ (reduced, ferrocytochrome c) and Fe³⁺ (oxidized, ferricytochrome c) during electron transfer, with a midpoint potential of +260 mV. |
| Structural compactness | The protein lacks significant disordered regions, contributing to its extreme stability (Tm > 80 °C) and evolutionary conservation (>95 % identity between human and horse sequences). |
| Associated Diseases | Als, Alzheimer, Dementia, Diabetes, Inflammation, Ms |
| Known Drugs/Compounds | rapamycin |
| Interactions | aco2, ACO2, ACTB, APP, ATG5, ATP |
| KG Connections | 355 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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