| Gene Symbol | COX4I1 |
| Full Name | Cytochrome C Oxidase Subunit 4I1 |
| Aliases | COX4I1PROTEIN |
| Chromosome | 16q24.1 |
| Protein Type | Enzyme |
| Target Class | Enzyme |
| Function | encodes a critical subunit of the mitochondrial electron transport chain Complex IV (cytochrome c oxidase). |
| Mechanism of Action | Drugs targeting COX4I1 pathway would enhance electron transport chain efficiency or stabilize complex IV assembly, improving ATP production and reducing oxidative stress in mitochondria. These agents work by either promoting mitochondrial bioenergetics, acting as electron donors/acceptors, or preventing complex IV degradation in diseases with impaired oxidative phosphorylation. |
| Primary Expression | Brain, Heart, Skeletal Muscle |
| Druggability | Low (0.42) |
| Clinical Stage | Phase II |
| Pathways | Mitochondrial dynamics / bioenergetics |
| UniProt ID | P12074 |
| NCBI Gene ID | 1024 |
| Ensembl ID | ENSG00000131043 |
| GeneCards | COX4I1 |
| Human Protein Atlas | COX4I1 |
| Associated Diseases | Aging, Cardiovascular, Ischemia, neurodegeneration |
| Known Drugs/Compounds | Elamipretide (MTP131), Idebenone, Coenzyme Q10 (Ubiquinone), SS-31 (Szeto-Schiller peptide 31) |
| Interactions | AGING, AIF1, AMPK, ARC, ATF3, AUTOPHAGY |
| SciDEX Target | View Target Profile (7 clinical trials) |
| SciDEX Hypotheses | Near-infrared light therapy stimulates COX4-depend |
| KG Connections | 325 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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