protein 588 words KG: CDC42PROTEIN
Contents

Cell Division Cycle 42 (Cdc42)

🔬 Protein Info
Gene SymbolCDC42PROTEIN
Chromosome1q25.3
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary Expressionthe central nervous system, with high levels in the hippocampus, cortex, and hypothalamus
GeneCardsCDC42PROTEIN
Human Protein AtlasCDC42PROTEIN
Rho family GTPasesRac1, RhoA
Upstream regulatorsTIAM1, βPIX, oligophrenin-1
Downstream effectorsPAK1/3, N-WASP, formins
Associated pathwaysPI3K/Akt signaling, actin polymerization
Disease associationsAlzheimer's disease, Parkinson's disease, autism spectrum disorders
Associated DiseasesAls, Alzheimer, Diabetes, Ferroptosis, Inflammation
InteractionsACTB, ACTG1, Actin, ACVR1, AGING, AKT
KG Connections416 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Related Hypotheses (10)

Senescent Cell Mitochondrial DNA Release
Score: 0.74
Synthetic Biology BBB Endothelial Cell Reprogramming
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Score: 0.70
Reelin-Mediated Cytoskeletal Stabilization Protocol
Score: 0.69
Grid Cell-Specific Metabolic Reprogramming via IDH2 Enhancem
Score: 0.65
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
TREM2-mediated microglial tau clearance enhancement
Score: 0.62
Astrocytic Lactate Shuttle Enhancement for Grid Cell Bioener
Score: 0.53

Related Analyses (9)

Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

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