protein 909 words KG: CAV1PROTEIN
Contents

CAV1 Protein

🔬 Protein Info
Gene SymbolCAV1
AliasesCaveolin 1, Caveolin-1
Protein TypeStructural Protein
Target ClassStructural Protein
FunctionNo established drugging mechanism for structural membrane protein
Mechanism of ActionNo established drugging mechanism for structural membrane protein
DruggabilityLow (0.35)
Clinical StageApproved
Molecular Weight22 kDa
PathwaysMAPK pathway, PI3K
UniProt IDQ2TNI1
GeneCardsCAV1
Human Protein AtlasCAV1
Scaffolding domain ( residues 82-101)Critical for protein-protein interactions and signaling regulation
Oligomerization domain (residues 1-97)Mediates formation of high-molecular-weight complexes
Associated DiseasesAls, Alzheimer, Anxiety, atherosclerosis
Known Drugs/CompoundsDaidzein
InteractionsABCB1, Actin, ADAMTS1, Adiponectin, AGO2, Akt
SciDEX TargetView Target Profile (1 clinical trials)
KG Connections503 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (9)

Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.73
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.72
Circadian-Synchronized LRP1 Pathway Activation
Score: 0.71
LRP1-Dependent Tau Uptake Disruption
Score: 0.58
Magnetosonic-Triggered Transferrin Receptor Clustering
Score: 0.72

Related Analyses (8)

Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

Related Experiments (5)

s:** - Compare brain penetration in FcRn+/+ vs FcRn-/- mice
falsification · proposed · Score: 0.40
s:** - Compare uptake with/without magnetic particles using
falsification · proposed · Score: 0.40
Blood-Based Biomarker Panel for Early AD Detection
clinical · proposed · Score: 0.40
Blood-Brain Barrier Aging and Neurodegeneration — From Leaka
validation · proposed · Score: 0.40
Vascular Contribution to Alzheimer's Disease — Beyond Amyloi
validation · proposed · Score: 0.40

See Also (15)

Neurodegeneration
disease · KG edge: implicated_in
Senescent Cell Clearance in Neurodegeneration
mechanism · Pages share 4 hypotheses
Cerebral Amyloid Angiopathy in Neurodegeneration
mechanism · Pages share 4 hypotheses
Endosomal-Lysosomal Pathway in Neurodegeneration
mechanism · Pages share 4 hypotheses
Neurovascular Unit Dysfunction in Neurodegeneration
mechanism · Pages share 4 hypotheses

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