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scidex_docs 604 words KG: apoe
Contents

APOE - Apolipoprotein E

🔬 Protein Info
Gene SymbolAPOE
Full NameApolipoprotein E
Chromosome19q13.32
Target ClassLigand
FunctionIt binds to the LDL receptor family to facilitate uptake of lipoprotein particles.
Mechanism of ActionProtein-protein interaction modulator or lipid metabolism enhancer
DruggabilityMedium (0.47)
Clinical StagePhase II
Molecular Weight34 kDa
PathwaysAmyloid, Autophagy, Blood-Brain Barrier, Brain Lipid Metabolism, Cholesterol
GeneCardsAPOE
Human Protein AtlasAPOE
Associated DiseasesAge Of Onset, Aging, alpha-synucleinopathies, Als
Known Drugs/Compoundsatherogenic lipoproteins, Crispr, curcumin, CURCUMIN
InteractionsA2M, ABC7 transporter, ABCA1, abca2, ABCA2, ABCA7
SciDEX TargetView Target Profile (8 clinical trials)
SciDEX HypothesesPrime Editing Precision Correction of APOE4 to APO
Selective APOE4 Degradation via Proteolysis Target
Competitive APOE4 Domain Stabilization Peptides (+18 more)
KG Connections4634 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

No AI portrait yet

Knowledge Graph

Related Hypotheses (30)

Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.72Cholesterol-CRISPR Convergence Therapy for Neurodegeneration
Score: 0.62Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79Competitive APOE4 Domain Stabilization Peptides
Score: 0.78

Related Analyses (30)

Lipid metabolism dysregulation and membrane integrity in Alz
neurodegeneration · completedTREM2 agonism vs antagonism in DAM microglia
neurodegeneration · completedMechanistic role of APOE in neurodegeneration
neurodegeneration · archivedWhat are the specific molecular determinants that govern tau
neurodegeneration · completedNeuroinflammation and microglial priming in early AD
neurodegeneration · completed

Related Experiments (30)

GWAS of plasma pTau217 in East Asian cohort
exploratory · proposed · Score: 0.95Dairy intake and dementia risk in Malmö Diet and Cancer coho
clinical · proposed · Score: 0.95GWAS of plasma pTau181 in East Asian cohort
exploratory · proposed · Score: 0.95GWAS of plasma GFAP in East Asian cohort
exploratory · proposed · Score: 0.95KEEPS Continuation: Long-term effects of menopausal hormone
clinical · proposed · Score: 0.95

See Also (15)

LX1001 Phase 1/2 Trial (NCT03634007) - Gene Therapy for
clinical · Pages share 10 hypothesesLX1001 Long-Term Follow-up (NCT05400330) - Gene Therapy
clinical · Pages share 10 hypothesesALA-enriched Nutrition for APOE4 Carriers with MCI (NCT
clinical · Pages share 9 hypothesesremternetug-anti-amyloid-alzheimers
clinical_trial · Pages share 9 hypothesesUPenn Observational Research Repository (NCT04715399)
clinical · Pages share 9 hypotheses

Knowledge Graph (6 edges)

apoe data_in ad_genetic_risk_loci:APOE
ad_genetic_risk_loci:APOE data_in apoe
apoe data_in benchmark_ot_ad_answer_key:APOE
benchmark_ot_ad_answer_key:APOE data_in apoe
apoe implicated_in neurodegeneration
entities-microglia-in-neurodegeneration interacts_with apoe

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