| Gene Symbol | ADORA2A |
| Full Name | Adenosine A2a Receptor |
| Aliases | ADORA2APROTEIN |
| Chromosome | 22q11.23 |
| Protein Family | GPCR |
| Target Class | Gpcr |
| Function | encodes a 412-amino acid protein primarily expressed in the striatum, olfactory tubercle, and nucleus accumbens. |
| Mechanism of Action | Small molecule antagonists blocking adenosine A2A receptor signaling |
| Primary Expression | the striatum, olfactory tubercle, and nucleus accumbens |
| Druggability | Medium (0.57) |
| Clinical Stage | Approved |
| Pathways | Apoptosis, Mitophagy, Oxidative Stress |
| GeneCards | ADORA2A |
| Human Protein Atlas | ADORA2A |
| Associated Diseases | als, alzheimer, ms, neurodegeneration |
| Known Drugs/Compounds | Istradefylline, Preladenant, CHEMBL3989695, CHEMBL3694769, CHEMBL3942498, CHEMBL197669 |
| Interactions | ALZHEIMER, ALZHEIMER DISEASE, AMBRA1, AUTOPHAGY, BCL2, BNIP3 |
| SciDEX Target | View Target Profile (8 clinical trials) |
| SciDEX Hypotheses | Adenosine-Astrocyte Metabolic Reset Parthenolide reduces tonic ADORA2A signaling by lo Parthenolide perturbs adenosine transport or metab (+2 more) |
| KG Connections | 139 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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