concept

PCGF1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PCGF1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

47Connections

0Hypotheses

0Analyses

40Outgoing

7Incoming

0Experiments

0Debates

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💡 Concept Info

Name	PCGF1
Key Genes/Proteins	EZH2, MAPK
Related Diseases	Adolescent Depression, Adolescent Major Depressive Disorder, depression, Depression, DEPRESSION
Related Pathways	Epigenetic, epigenetic regulation, Histone Modification, Mapk, MAPK signaling

Pathway Diagram

graph TD
    PCGF1["PCGF1"]
    PCGF1 -->|"inhibits"| Neuroinflammation["Neuroinflammation"]
    PCGF1 -->|"inhibits"| MMP10["MMP10"]
    PCGF1 -.protects against.-> Depression_Like_Behavior["Depression-Like Behavior"]
    PCGF1 -.protects against.-> Adolescent_Depression["Adolescent Depression"]
    PCGF1 -->|"inhibits"| NF__B_MAPK_Pathway["NF-kappaB/MAPK Pathway"]
    PCGF1 -->|"expressed in"| Microglia["Microglia"]
    PCGF1 -->|"downregulates"| Adolescent_Major_Depressive_Di["Adolescent Major Depressive Disorder"]
    DEPRESSION["DEPRESSION"] -->|"inhibits"| PCGF1
    SYNAPSE["SYNAPSE"] -->|"regulates"| PCGF1
    NEUROINFLAMMATION["NEUROINFLAMMATION"] -->|"inhibits"| PCGF1
    MICROGLIA["MICROGLIA"] -->|"inhibits"| PCGF1
    MMP10 -->|"activates"| PCGF1

Outgoing (40)

Target	Relation	Type	Str
MMP10	inhibits	gene	0.95
Depression-Like Behavior	associated_with	phenotype	0.95
Neuroinflammation	inhibits	process	0.95
MMP10	downregulates	gene	0.94
Depression-Like Behavior	protects_against	phenotype	0.93
Adolescent Depression	protects_against	disease	0.92
NF-κB/MAPK Pathway	inhibits	pathway	0.91
Nf-Κb/Mapk Pathway	inhibits	pathway	0.90
Microglia	expressed_in	cell_type	0.90
Adolescent Major Depressive Disorder	downregulates	disease	0.90
RING1B	upregulates	gene	0.90
EZH2	upregulates	gene	0.90
Adolescent Depression	biomarker_for	disease	0.85
neuroinflammation	alleviates	process	0.80
DEPRESSION	protects_against	disease	0.70
Depression	inhibits	disease	0.65
Inflammation	inhibits	disease	0.65
MAPK	activates	gene	0.60
DEPRESSION	inhibits	gene	0.60
EZH2	activates	gene	0.60
NF-ΚB	activates	gene	0.60
RING1B	activates	gene	0.60
MMP10	activates	gene	0.60
Mapk	activates	pathway	0.60
Epigenetic	expressed_in	pathway	0.60
Nf-Κb	activates	pathway	0.60
Histone Modification	regulates	pathway	0.60
Microglia	inhibits	cell_type	0.60
Neuron	inhibits	cell_type	0.60
depression	regulates	disease	0.60
epigenetic regulation	participates_in	pathway	0.60
microglia	expressed_in	cell_type	0.60
neuroinflammation	regulates	disease	0.60
neurons	expressed_in	cell_type	0.60
neuroinflammation	activates	disease	0.60
MAPK signaling	participates_in	pathway	0.60
NF-kB signaling	participates_in	pathway	0.60
SYNAPSE	regulates	gene	0.60
MICROGLIA	inhibits	gene	0.60
Neuron	expressed_in	cell_type	0.55

Incoming (7)

Source	Relation	Type	Str
DEPRESSION	inhibits	gene	0.60
EZH2	activates	gene	0.60
MAPK	activates	gene	0.60
SYNAPSE	regulates	gene	0.60
NEUROINFLAMMATION	inhibits	gene	0.60
MICROGLIA	inhibits	gene	0.60
MMP10	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PCGF1 in their description or question text

No additional research found