| Gene Symbol | P2RY12 |
| Full Name | Purinergic Receptor P2Y12 |
| Aliases | P2RY12PROTEIN |
| Chromosome | 3q25.1-q25.2 |
| Protein Type | Gpcr |
| Target Class | Gpcr |
| Function | P2RY12 is a Gi/o protein-coupled receptor for ADP that plays a critical role in microglial surveillance and neuroimmune responses in the brain. |
| Mechanism of Action | P2Y12 receptor antagonists blocking ADP-mediated signaling |
| Subcellular Localization | </b></td><td>Plasma Membrane, Microglial Processes</td></tr> |
| Druggability | Medium (0.55) |
| Clinical Stage | Approved |
| Pathways | PI3K, MAPK |
| UniProt ID | Q9H244 |
| NCBI Gene ID | 29128 |
| Ensembl ID | ENSG00000170017 |
| GeneCards | P2RY12 |
| Human Protein Atlas | P2RY12 |
| Associated Diseases | AD, Aging, Als, Alzheimer |
| Known Drugs/Compounds | rapamycin, statins |
| Interactions | 4E-BP1, ABCA1, ABCG1, ACTB, Actin, AD |
| SciDEX Target | View Target Profile (8 clinical trials) |
| SciDEX Hypotheses | Purinergic P2Y12 Inverse Agonist Therapy Microglial Purinergic Reprogramming P2RY12-mediated autophagy inhibition in cerebral V (+6 more) |
| KG Connections | 596 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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