mechanism 3,665 words KG: ent-gene-28e2cb01
Contents

TREM2→Microglial Dysfunction→Alzheimer's Disease Causal Chain

🔬 Protein Info
Gene Symbolent-gene-28e2cb01
Chromosome6p21.1
Extracellular domainV-type immunoglobulin-like domain for ligand binding [3]
Transmembrane domainSingle pass with DAP12 (TYROBP) adaptor [3]
Intracellular tailContains ITAM motif for signaling [3]
LipidsApolipoproteins (ApoE, ApoA1), oxidized phospholipids [4]
Lipidated proteinsAmyloid-beta, TDP-43 [4]
Bacterial componentsLPS, lipoteichoic acid [4]
KG Connections94 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

Wikipedia

Related Hypotheses (45)

Gamma entrainment therapy to restore hippocampal-cortical sy
Score: 0.90
ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro
Score: 0.87
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Prefrontal sensory gating circuit restoration via PV interne
Score: 0.78
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
SIRT3-Mediated Mitochondrial Deacetylation Failure with PINK
Score: 0.74
Complement C1QA Spatial Gradient in Cortical Layers
Score: 0.68
Excitatory Neuron Vulnerability via SLC17A7 Downregulation
Score: 0.67
Astrocyte MCT1/MCT4 Ratio Disruption with Metabolic Uncoupli
Score: 0.67
TREM2-mediated microglial tau clearance enhancement
Score: 0.62
LRP1-Dependent Tau Uptake Disruption
Score: 0.60
VCP-Mediated Autophagy Enhancement
Score: 0.59
Extracellular Vesicle Biogenesis Modulation
Score: 0.58
Synaptic Vesicle Tau Capture Inhibition
Score: 0.58
HSP90-Tau Disaggregation Complex Enhancement
Score: 0.57
Trans-Synaptic Adhesion Molecule Modulation
Score: 0.54
APOE-TREM2 Interaction Modulation
Score: 0.74
Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.73
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Related Analyses (30)

Astrocyte Reactivity Subtypes in Neurodegeneration
neurodegeneration · archived
Neuroinflammation and microglial priming in early AD
neurodegeneration · completed
Immune atlas neuroinflammation analysis in neurodegeneration
Neuroinflammation · completed
What are the optimal timing windows for TREM2 agonism vs ant
neurodegeneration · archived
Does SYK activation provide neuroprotection or exacerbate ne
neurodegeneration · archived

Related Experiments (30)

TREM2 Agonist Therapy for Parkinson's Disease — Experimental
validation · proposed · Score: 0.45
Microglial TREM2 Agonist In Vivo Efficacy
validation · proposed · Score: 0.45
TREM2 Function in Alzheimer's Disease — From Risk Variant to
validation · proposed · Score: 0.45
TREM2 KO amyloid pathology study
validation · completed · Score: 0.80
TREM2 KO amyloid pathology study
validation · completed · Score: 0.80

See Also (15)

ASL Perfusion Biomarkers for Alzheimer's Disease
biomarker · Pages share 18 hypotheses
Digital Biomarkers for Alzheimer's Disease
biomarker · Pages share 18 hypotheses
Dried Blood Spot Biomarker Test for Alzheimer's Disease
biomarker · Pages share 18 hypotheses
DTI Biomarkers for Alzheimer's Disease
biomarker · Pages share 18 hypotheses
EEG Biomarkers for Alzheimer's Disease
biomarker · Pages share 18 hypotheses

Knowledge Graph (12 edges)

h-var-a8c6c6ea92 targets ent-gene-28e2cb01
ent-gene-28e2cb01 targeted_by h-var-a8c6c6ea92
ent-gene-28e2cb01 targeted_by h-b490c14bf6
h-dffb42d9de targets ent-gene-28e2cb01
ent-gene-28e2cb01 targeted_by h-dffb42d9de
h-var-223b8be521 targets ent-gene-28e2cb01
ent-gene-28e2cb01 targeted_by h-var-223b8be521
h-64e3588957 targets ent-gene-28e2cb01
ent-gene-28e2cb01 targeted_by h-64e3588957
h-var-42a172bc53 targets ent-gene-28e2cb01

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