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mechanism 2,366 words KG: ent-gene-58ffe46a
Contents

SYK Kinase in Microglial Activation and Alzheimer's Disease

🔬 Protein Info
Gene Symbolent-gene-58ffe46a
Active SYK> VAV/Rac -> cytoskeletal reorganization for particle engulfment
Suppressed SYK> NF-kappaB -> sustained inflammatory cytokine production
DAM1Early-stage microglia with increased SYK activity, enhanced phagocytic capacity
DAM2Late-stage microglia with suppressed SYK, dominated by inflammatory gene expression
KG Connections11 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Wikipedia

Related Hypotheses (47)

Microglial Purinergic Reprogramming
Score: 0.70Metabolic Reprogramming via Microglial Glycolysis Inhibition
Score: 0.67Optogenetic Microglial Deactivation via Engineered Inhibitor
Score: 0.66TREM2-Mediated Selective Aggregate Clearance Pathway
Score: 0.58TREM2-Dependent Microglial Senescence Transition
Score: 0.58Targeted Butyrate Supplementation for Microglial Phenotype M
Score: 0.70Context-Dependent CRISPR Activation in Specific Neuronal Sub
Score: 0.68
← Prevpg 3/3

Related Analyses (30)

Does SYK activation provide neuroprotection or exacerbate ne
neurodegeneration · archivedSEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archivedTDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archivedAstrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived

Related Experiments (30)

Microglial Aging and Immune Memory in Neurodegeneration — Tr
validation · proposed · Score: 0.40Cytochrome Therapeutics
clinical · proposed · Score: 0.40ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40CSF Dynamic Biomarkers for Differential Diagnosis of NPH vs
clinical · proposed · Score: 0.90Brain Connectivity-Targeted tACS Trial in Early AD
clinical · proposed · Score: 0.51

See Also (15)

GFAP in Alzheimer's Disease
biomarker · Pages share 18 hypothesesOlfactory Biomarkers for Alzheimer's Disease
biomarker · Pages share 18 hypothesesAlzheimer's Disease Biomarkers
biomarker · Pages share 18 hypothesesASL Perfusion Biomarkers for Alzheimer's Disease
biomarker · Pages share 18 hypothesesNPTX1 and NPTXR CSF Markers Predict Alzheimer's Disease
biomarker · Pages share 21 hypotheses

Knowledge Graph (11 edges)

h-5d753df0 targets ent-gene-58ffe46a
ent-gene-58ffe46a targeted_by h-5d753df0
h-6358a464ac targets ent-gene-58ffe46a
ent-gene-58ffe46a targeted_by h-6358a464ac
36257314 critically regulates ent-gene-58ffe46a
h-15a8468c targets ent-gene-58ffe46a
ent-gene-58ffe46a targeted_by h-15a8468c
ent-gene-58ffe46a data_in benchmark_ot_ad_answer_key:SYK
benchmark_ot_ad_answer_key:SYK data_in ent-gene-58ffe46a
h-9f5ce0a588 targets ent-gene-58ffe46a

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