Contents

SYK Kinase in Microglial Activation and Alzheimer's Disease

🔬 Protein Info

Gene Symbol	ent-gene-58ffe46a
Active SYK	> VAV/Rac -> cytoskeletal reorganization for particle engulfment
Suppressed SYK	> NF-kappaB -> sustained inflammatory cytokine production
DAM1	Early-stage microglia with increased SYK activity, enhanced phagocytic capacity
DAM2	Late-stage microglia with suppressed SYK, dominated by inflammatory gene expression
KG Connections	11 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

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