| Edinger-Westphal nucleus | Tau pathology in parasympathetic output |
| Pretectal area | Light reflex pathway involvement |
| Superior colliculus | Visual integration center |
| Hypothalamus | Autonomic regulation |
| Ciliary ganglion | Post-ganglionic involvement |
| Sympathetic dysfunction | Reduced pupillary dilation |
| Parasympathetic impairment | Reduced constriction |
| Dysautonomia correlation | Orthostatic hypotension link |
| Reduced constriction amplitude | <2mm in bright light |
| Prolonged constriction latency | >300ms delay |
| Impaired dilation | Slow or incomplete |
| Light-near dissociation | Present in some cases |
| KG Connections | 3 knowledge graph edges |
| Databases | OMIMOrphanetClinicalTrialsPubMed |
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