Contents

CSF Biomarkers for Corticobasal Syndrome and Progressive Supranuclear Palsy

🔬 Protein Info

Gene Symbol	CSF
Elevated in	CBS due to AD pathology, but also elevated in CBS/PSP due to primary tauopathies[@smith2025]
Pattern differences	CBS-AD shows higher levels than CBS-PSP, reflecting the greater AD-related neurodegeneration
Utility	Non-specific marker of neuronal damage; elevated levels seen in both CBS and PSP but cannot reliably differentiate between underlying pathologies
Prognostic value	Higher baseline levels correlate with more rapid clinical progression
Longitudinal changes	Annual increases in t-tau predict clinical deterioration in both CBS and PSP
Tau oligomers	Elevated in CBS and PSP, reflecting the presence of aggregated tau species
Tau seed amplification assays	Can distinguish between different tauopathy subtypes using novel techniques like salt-modulated tau amplification[@classification2026]
Tau RT-QuIC	Detects tau seeding activity in CSF, differentiating 4R tauopathies from alpha-synucleinopathies[@ahmad2024]
Disease-specific tau strains	Different aggregation properties between CBD/PSP tau and AD tau
Reduced ratio	Indicates amyloid pathology, suggesting CBS-AD subtype
Associated Diseases	MULTIPLE SCLEROSIS
Known Drugs/Compounds	ADUCANUMAB
KG Connections	125 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING