| Gene Symbol | OTULIN |
| Full Name | Tau Regulation Pathway |
| Aliases | OTU Deubiquitinase with Linear Linkage Specificity |
| Chromosome | 5p15.2 |
| Protein Type | Protease |
| Function | Unlike other OTU family members, OTULIN shows exceptional specificity for linear ubiquitin chains and does not efficiently cleave other ubiquitin linkage types. |
| Pathways | NF-κB signaling, NF-κB Signaling, NF-κB |
| Ensembl ID | ENSG00000135547 |
| GeneCards | OTULIN |
| Human Protein Atlas | OTULIN |
| Neuroinflammation | NF-κB activation drives tau expression |
| Ubiquitin system | Linear ubiquitination specifically dysregulated |
| Protein homeostasis | Tau synthesis rate modulation |
| Disease progression | Therapeutic implications |
| Associated Diseases | Infection, Inflammation |
| Interactions | IKBKG, INFLAMMATION, MITOCHONDRIA, NFKB, NF-ΚB, PINK1 |
| KG Connections | 38 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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