| Gene Symbol | ent-gene-c80bcf41 |
| Function | 1. Early disease (anti-phagocytic): Excessive SHIP1 activity impairs microglial engagement with amyloid plaques, reducing beneficial phagocytosis |
| 5'-phosphatase domain | Catalytic activity hydrolyzing PIP3 to PIP2 |
| C-terminal proline-rich region | Mediates protein-protein interactions |
| NPXY motifs | Support endocytic trafficking |
| Microglial specificity | Expression in brain is restricted to microglia |
| AD-specific changes | Paradoxically increased mRNA but with truncated protein |
| Disease stage effects | Opposing roles at different disease stages |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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