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mechanism 3,424 words KG: excitotoxicity
Contents

Excitotoxicity Pathway

⚙ Mechanism Info
Nameexcitotoxicity
Key Genes/ProteinsACSL4, AQP1, AQP4, BDNF, BMAL1, BNIP3
Related DiseasesAlzheimer's Disease, Amyotrophic lateral sclerosis
Related Pathwaysautophagy, ferroptosis

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Knowledge Graph

Agent Input

Related Hypotheses (57)

Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69Ganglioside Rebalancing Therapy
Score: 0.69Flotillin-1 Stabilization Compounds
Score: 0.68Chaperone-Mediated APOE4 Refolding Enhancement
Score: 0.68Complement C1QA Spatial Gradient in Cortical Layers
Score: 0.68Excitatory Neuron Vulnerability via SLC17A7 Downregulation
Score: 0.67Aquaporin-4 Polarization Enhancement via TREK-1 Channel Modu
Score: 0.67Biorhythmic Interference via Controlled Sleep Oscillations
Score: 0.66Mitochondrial RNA Granule Rescue Pathway
Score: 0.66Arginine Methylation Enhancement Therapy
Score: 0.65Microbial Inflammasome Priming Prevention
Score: 0.65FOXO3-Longevity Pathway Epigenetic Reprogramming
Score: 0.63Synaptic Phosphatidylserine Masking via Annexin A1 Mimetics
Score: 0.62SIRT6-NAD+ Axis Enhancement Therapy
Score: 0.61Astrocytic Connexin-43 Upregulation Enhances Neuroprotective
Score: 0.56Lysosomal Membrane Repair Enhancement
Score: 0.54Cryptic Exon Silencing Restoration
Score: 0.53
← Prevpg 3/3

Related Analyses (30)

RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archivedSynaptic pruning by microglia in early AD
neurodegeneration · archivedMitochondrial transfer between astrocytes and neurons
neurodegeneration · archivedEpigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archivedPerivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived

See Also (3)

ACSL4 Gene - Acyl-CoA Synthetase Long Chain Family Memb
gene · KG edge: debate_co_mentionAlzheimer Indonesia
institution · KG edge: activatesPackard Center for ALS Research
institution · KG edge: associated_with

Knowledge Graph (12 edges)

glutamate_receptors causes excitotoxicity
glutamate receptors causes excitotoxicity
ginsenosides inhibits excitotoxicity
excitotoxicity associated_with Amyotrophic lateral sclerosis
SLC1A3 protects_against excitotoxicity
excitotoxicity activates STIM1
excitotoxicity co_mentioned neuroinflammation
excitotoxicity co_mentioned ferroptosis
excitotoxicity associated_with neuroinflammation
excitotoxicity activates SST

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