gene 843 words KG: SLC1A3
Contents

slc1a3 Gene

🧬 Gene Info
Gene SymbolSLC1A3
Full NameSolute Carrier Family 1 Member 3
Chromosome5p13.2
Protein TypeTransporter
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary Expressionastrocytes and plays a critical role in maintaining extracellular glutamate homeostasis in the central nervous system by clearing glutamate from the s
Molecular Weight59 kDa
Pathwaysclimbing fiber innervation, glutamate clearance, glutamate transport, synaptic wrapping
UniProt IDP43003
NCBI Gene ID6507
Ensembl IDENSG00000081189
OMIM600116
GeneCardsSLC1A3
Human Protein AtlasSLC1A3
Associated DiseasesAls, Alzheimer's disease, auditory function, spinocerebellar ataxia
Known Drugs/Compoundsarundic acid
InteractionsALS, ALZHEIMER, ALZHEIMER'S DISEASE, APP, APP/PS1, ASC
KG Connections63 knowledge graph edges
DatabasesGeneCardsHPASTRING

No AI portrait yet

Knowledge Graph

Related Hypotheses (3)

CYP46A1 Overexpression Gene Therapy
Score: 0.95
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69

Related Analyses (3)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (13)

Astrocytes
cell · KG edge: activates
Astrocytes
entity · KG edge: activates
GFAP (Redirect)
redirect · KG edge: regulates
Epigenetic Clocks in Neurodegeneration — Causal Drivers
experiment · KG edge: activates
ASC (PYCARD)
gene · KG edge: activates

Knowledge Graph (12 edges)

NLRP3 activates SLC1A3
ASC activates SLC1A3
SLC1A3 activates APP
SLC1A3 involved_in synaptic wrapping
SLC1A3 involved_in glutamate transport
SLC1A3 expressed_in Bergmann glia
SLC1A3 involved_in climbing fiber innervation
SLC1A3 associated_with auditory function
SLC1A3 associated_with synaptic pathology
SLC1A3 implicated_in spinocerebellar ataxia

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