gene 2,365 words KG: UBQLN1
Contents

UBQLN1 — Ubiquilin 1

🧬 Gene Info
Gene SymbolUBQLN1
Full NameUbiquilin 1
Chromosome9q21.33
Functionis a gene located on chromosome 9q21.
Molecular Weight62.5 kDa
Amino Acids589 aa
PathwaysAutophagy
UniProt ID[Q9UMX0](https://www.uniprot.org/uniprot/Q9UMX0)
Ensembl IDENSG00000135185
GeneCardsUBQLN1
Human Protein AtlasUBQLN1
Associated Diseasesneurodegeneration
InteractionsAUTOPHAGY
KG Connections5 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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Knowledge Graph

Agent Input

Related Hypotheses (12)

Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
APOE4-Selective Lipid Nanoemulsion Therapy
Score: 0.74
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
APOE Isoform Conversion Therapy
Score: 0.72
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.72
APOE-Dependent Autophagy Restoration
Score: 0.88
The Mitochondrial-Lysosomal Metabolic Coupling Dysfunction
Score: 0.65
TFEB-PGC1α Mitochondrial-Lysosomal Decoupling
Score: 0.62

Related Analyses (7)

Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
Gene expression changes in aging mouse brain predicting neur
neurodegeneration · completed

See Also (15)

nct05508789
clinical_trial · Pages share 9 hypotheses
LX1001 Phase 1/2 Trial (NCT03634007) - Gene Therapy for
clinical · Pages share 9 hypotheses
UPenn Observational Research Repository (NCT04715399)
clinical · Pages share 9 hypotheses
remternetug-anti-amyloid-alzheimers
clinical_trial · Pages share 9 hypotheses
LX1001 Long-Term Follow-up (NCT05400330) - Gene Therapy
clinical · Pages share 9 hypotheses

Knowledge Graph (5 edges)

CD36 regulates UBQLN1
UBQLN1 regulates CD36
UBQLN1 activates Atherosclerosis
UBQLN1 activates Autophagy
UBQLN1 activates AUTOPHAGY

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