gene 2,210 words KG: TMEM55B
Contents

TMEM55B — Transmembrane Protein 55B

🧬 Gene Info
Gene SymbolTMEM55B
Full NameTransmembrane Protein 55B
Chromosome14q11.2
Functionis a gene on chromosome 14q11.
Primary ExpressionBrain, Substantia Nigra, lysosomal compartments
Subcellular Localizationendolysosomal membranes where it regulates phosphatidylinositol (PI) signaling and lysosomal function
Amino Acids277 aa
UniProt IDQ86T03
NCBI Gene ID90809
Ensembl IDENSG00000100889
OMIM609865
GeneCardsTMEM55B
Human Protein AtlasTMEM55B
Associated DiseasesAlzheimer's Disease, BMD
InteractionsJIP4, LRRK2, WDR81
KG Connections18 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

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Related Hypotheses (11)

Transcriptional Autophagy-Lysosome Coupling
Score: 0.92
Gamma entrainment therapy to restore hippocampal-cortical sy
Score: 0.90
Autophagosome Maturation Checkpoint Control
Score: 0.71
VCP-Mediated Autophagy Enhancement
Score: 0.59
APOE-Dependent Autophagy Restoration
Score: 0.88
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
Lysosomal Positioning Dynamics Modulation
Score: 0.69
The Mitochondrial-Lysosomal Metabolic Coupling Dysfunction
Score: 0.65
TFEB-PGC1α Mitochondrial-Lysosomal Decoupling
Score: 0.62
Pharmacological Enhancement of APOE4 Glycosylation
Score: 0.62
Extracellular Vesicle Biogenesis Modulation
Score: 0.58

Related Analyses (3)

Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived

Related Experiments (5)

Anti-Tau Antibody vs ASO/Gene Therapy — Comparative Efficacy
validation · proposed · Score: 0.40
CRISPR Gene Correction Approaches for CBS/PSP
clinical · proposed · Score: 0.40
Validate Mitochondria-Lysosome Contact Site Dysfunction in P
validation · proposed · Score: 0.40
Non-Motor Symptom Progression in Parkinson's Disease — Mecha
clinical · proposed · Score: 0.40
Spinocerebellar Ataxia (SCA) Disease-Modifying Therapy Devel
validation · proposed · Score: 0.40

See Also (6)

Neurodegeneration
disease · KG edge: implicated_in
TFEB (Redirect)
redirect · KG edge: upregulates
CTNS Gene
gene · KG edge: associated_with
LDLR Gene
gene · KG edge: regulates
TFE3 Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

TMEM55B regulates CTNS
TMEM55B contributes_to V-ATPase
TMEM55B activates mTORC1
TMEM55B regulates LDLR
TMEM55B associated_with BMD
TMEM55B upregulates phosphatases
TMEM55B associated_with PLEKHM1
TMEM55B associated_with ESCRT machinery
TMEM55B associated_with FLCN/FNIP complex
JIP4 inhibits TMEM55B

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