| Gene Symbol | SLC22A4 |
| Full Name | Solute Carrier Family 22 Member 4 (OCTN1) |
| Chromosome | 5q31.1 |
| Function | Ergothioneine Transport: OCTN1 is the primary high-affinity transporter for ergothioneine, a potent antioxidant that cannot be synthesized by humans and must be obtained from diet (mushrooms, certain |
| Amino Acids | 553 aa |
| UniProt ID | Q9H001 |
| NCBI Gene ID | 6582 |
| Ensembl ID | ENSG00000145040 |
| GeneCards | SLC22A4 |
| Human Protein Atlas | SLC22A4 |
| Antioxidant Defense | Ergothioneine scavenges reactive oxygen species (ROS) and prevents oxidative damage |
| Mitochondrial Protection | Preserves mitochondrial function under stress |
| Neuroinflammation Modulation | Reduces microglial activation and inflammatory cytokine production |
| Oxidative Stress | Impaired ergothioneine transport reduces antioxidant capacity |
| Amyloid Interactions | Ergothioneine may interact with amyloid-beta to reduce its toxicity |
| Associated Diseases | Alzheimer's disease, Parkinson's disease |
| Interactions | INFLAMMATION |
| KG Connections | 17 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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