| Gene Symbol | PRKCQ |
| Protein Type | Kinase |
| Function | PRKCQ is a serine/threonine kinase with several distinctive functional features: |
| Primary Expression | T-cells and certain neuronal populations, where it plays critical roles in T-cell receptor signaling, synaptic plasticity, and neuronal survival [@bai |
| Pathways | NF-κB |
| GeneCards | PRKCQ |
| Human Protein Atlas | PRKCQ |
| DAG-binding C1 Domain | Mediates responsiveness to diacylglycerol and phorbol esters without requiring calcium [@baierbitterlich1996]. |
| C3/C4 ATP-binding Domain | Catalytic domain with kinase activity. |
| Atypical PKC Interaction | Can interact with other atypical PKCs (ζ, λ/ι) in certain cellular contexts [@hanse2013]. |
| Synaptic Plasticity | In neurons, PRKCQ localizes to presynaptic terminals and regulates neurotransmitter release, long-term potentiation (LTP), and learning and memory [@altman2002]. |
| Cytoskeletal Reorganization | Controls actin cytoskeleton dynamics through phosphorylation of downstream substrates, affecting cell morphology and migration [@moscat2000]. |
| [Tau](/proteins/tau) Phosphorylation | PKC signaling pathways can influence tau phosphorylation through direct phosphorylation of tau kinases (GSK-3β, CDK5) and phosphatases [@cheng2011]. |
| Synaptic Dysfunction | Given its role in synaptic plasticity, altered PRKCQ signaling may contribute to synaptic deficits in AD [@altman2002]. |
| Mitochondrial Dysfunction | PRKCQ signaling may intersect with mitochondrial pathways relevant to dopaminergic neuron survival [@fujiwara2003]. |
| Associated Diseases | neurodegeneration |
| Interactions | AUTOPHAGY, FERROPTOSIS |
| KG Connections | 7 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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