gene 3,179 words KG: PRDX2
Contents

PRDX2 — Peroxiredoxin 2

🧬 Gene Info
Gene SymbolPRDX2
Full NamePeroxiredoxin 2
Chromosome19p13.13
Protein TypeEnzyme
Functionis a critical antioxidant enzyme in the neurobiology of neurodegenerative diseases.
Primary ExpressionErythrocytes, Brain, Liver, Kidney, Heart
Molecular Weight22 kDa
Amino Acids198 aa
UniProt IDP32189
NCBI Gene ID7003
Ensembl IDENSG00000167612
OMIM607386
GeneCardsPRDX2
Human Protein AtlasPRDX2
N-terminal regionContains the first conserved cysteine (Cys⁵¹)
Associated DiseasesParkinson's disease, Alzheimer's disease
KG Connections14 knowledge graph edges
DatabasesGeneCardsHPASTRING

No AI portrait yet

Knowledge Graph

Related Hypotheses (5)

ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro
Score: 0.85
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
Extracellular Matrix Stiffness Modulation
Score: 0.69
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69
TREM2-mediated microglial tau clearance enhancement
Score: 0.62

Related Analyses (3)

SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
Synaptic pruning by microglia in early AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (8)

Neurodegeneration
disease · KG edge: implicated_in
Microglia in Neurodegeneration
entity · KG edge: upregulates
TREM2 Protein (Triggering Receptor Expressed on Myeloid
entity · KG edge: upregulates
AP2B1 — Adaptor Related Protein Complex 2 Subunit Beta
gene · KG edge: associated_with
GRB2 — Growth Factor Receptor Bound Protein 2
gene · KG edge: associated_with

Knowledge Graph (12 edges)

NR3C1 associated_with PRDX2
TXN associated_with PRDX2
AP2B1 associated_with PRDX2
GRB2 associated_with PRDX2
PRDX2 associated_with PIK3C3
PRDX2 upregulates TREM2
OxPC activates PRDX2
PRDX2 expressed_in Als
PRDX2 expressed_in Ms
microglia upregulates PRDX2

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