| Gene Symbol | PPM1B |
| Full Name | Protein Phosphatase Mg2+/Mn2+ Dependent 1B |
| Chromosome | 2p21 |
| Protein Type | Serine/Threonine Phosphatase |
| Function | p38 MAPK Pathway: Dephosphorylates and inactivates p38 MAPK, reducing stress-induced apoptosis |
| Subcellular Localization | and protein interactions |
| Amino Acids | 471 aa |
| Pathways | MAPK |
| UniProt ID | [Q06180](https://www.uniprot.org/uniprot/Q06180) |
| Ensembl ID | ENSG00000172548 |
| OMIM | 608002 |
| GeneCards | PPM1B |
| Human Protein Atlas | PPM1B |
| Metal Ion Dependence | Requires Mg2+ or Mn2+ for phosphohydrolase activity |
| Substrate Specificity | Prefers serine and threonine residues in specific contexts |
| Associated Diseases | ALS |
| Interactions | AMPK, AUTOPHAGY, MLKL |
| KG Connections | 14 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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