gene 916 words KG: NCT
Contents

NCT (Nicastrin) Gene

🧬 Gene Info
Gene SymbolNCT
Full NameNicastrin
Chromosome1p31.3
Functionis an important component in the neurobiology of neurodegenerative diseases.
Subcellular Localization) modifies this processivity context with presenilin variants, creating an interaction layer between genetic background
Pathwayscircadian regulation
UniProt IDQ92542
NCBI Gene ID51594
Ensembl IDENSG00000103546
GeneCardsNCT
Human Protein AtlasNCT
Associated DiseasesAlzheimer
InteractionsAPH1, APP, PS1, PSEN, TAU, VCP
KG Connections15 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (14)

SASP-Mediated Cholinergic Synapse Disruption
Score: 0.76
Sleep Spindle-Synaptic Plasticity Enhancement
Score: 0.72
Lysosomal Enzyme Trafficking Correction
Score: 0.71
Lysosomal Calcium Channel Modulation Therapy
Score: 0.70
Lysosomal Positioning Dynamics Modulation
Score: 0.69
Excitatory Neuron Vulnerability via SLC17A7 Downregulation
Score: 0.67
Mitochondrial-Lysosomal Contact Site Engineering
Score: 0.67
Synaptic Phosphatidylserine Masking via Annexin A1 Mimetics
Score: 0.62
Trans-Synaptic Adhesion Molecule Modulation
Score: 0.54
Lysosomal Membrane Repair Enhancement
Score: 0.54
Piezoelectric Nanochannel BBB Disruption
Score: 0.52
CYP46A1 Overexpression Gene Therapy
Score: 0.95
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Palmitoylation-Targeted BACE1 Trafficking Disruptors
Score: 0.69

Related Analyses (5)

Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Microglial subtypes in neurodegeneration — friend vs foe
neuroscience · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Sleep disruption as cause and consequence of neurodegenerati
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

Cytochrome Therapeutics
clinical · proposed · Score: 0.40

See Also (15)

Exosomal Biomarkers in Neurodegeneration
biomarker · Pages share 9 hypotheses
Exosomal miR-155 in Neurodegeneration
biomarker · Pages share 9 hypotheses
IL-6 (Interleukin-6) in Neurodegeneration
biomarker · Pages share 9 hypotheses
Liquid Biopsy in Neurodegeneration
biomarker · Pages share 9 hypotheses
Metabolomic Biomarkers in Neurodegeneration
biomarker · Pages share 9 hypotheses

Knowledge Graph (12 edges)

NCT participates_in circadian regulation
TAU interacts_with NCT
APH1 activates NCT
NCT activates PSEN
APP regulates NCT
APP activates NCT
NCT interacts_with neurodegeneration
NCT interacts_with VCP
NCT activates VCP
NCT associated_with Alzheimer

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