gene 3,347 words KG: KDM3A
Contents

KDM3A Gene (JMJD1A)

🧬 Gene Info
Gene SymbolKDM3A
Chromosome2p11.2
Protein TypeEnzyme
Functionis a nuclear enzyme that catalyzes the removal of methyl groups from histone H3 at lysine 9 (H3K9), a modification associated with transcriptional repression.
Primary Expressionneurons and glial cells throughout the brain, where it regulates genes critical for neuronal survival, differentiation, synaptic plasticity, and respo
Molecular Weight164 kDa
Amino Acids474 aa
Exons23
UniProt IDQ9N3T2
NCBI Gene ID55630
Ensembl IDENSG00000188290
OMIM607442
GeneCardsKDM3A
Human Protein AtlasKDM3A
Associated Diseasesneurodegeneration
InteractionsCANCER, HIF1, HIF1A, UBIQUITIN
KG Connections6 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (20)

Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
APOE4-Selective Lipid Nanoemulsion Therapy
Score: 0.74
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
APOE Isoform Conversion Therapy
Score: 0.72
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.72
Metabolic Switch Targeting for A1→A2 Repolarization
Score: 0.73
Metabolic Reprogramming via Microglial Glycolysis Inhibition
Score: 0.67
APOE-Dependent Autophagy Restoration
Score: 0.85
AMPK hypersensitivity in astrocytes creates enhanced mitocho
Score: 0.81
Smartphone-Detected Motor Variability Correction
Score: 0.74
Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.73
Grid Cell-Specific Metabolic Reprogramming via IDH2 Enhancem
Score: 0.65
Epigenetic Memory Reprogramming for Alzheimer's Disease
Score: 0.61
PINK1/Parkin-Independent Mitophagy Bypass for Enhanced Donor
Score: 0.53
Microbial Metabolite-Mediated α-Synuclein Disaggregation
Score: 0.51
Enteric Nervous System Prion-Like Propagation Blockade
Score: 0.48

Related Analyses (11)

Synaptic pruning by microglia in early AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completed

See Also (15)

nct05508789
clinical_trial · Pages share 9 hypotheses
LX1001 Phase 1/2 Trial (NCT03634007) - Gene Therapy for
clinical · Pages share 9 hypotheses
UPenn Observational Research Repository (NCT04715399)
clinical · Pages share 9 hypotheses
remternetug-anti-amyloid-alzheimers
clinical_trial · Pages share 9 hypotheses
LX1001 Long-Term Follow-up (NCT05400330) - Gene Therapy
clinical · Pages share 9 hypotheses

Knowledge Graph (6 edges)

KDM3A activates UBIQUITIN
KDM3A activates HIF1A
KDM3A activates HIF1
KDM3A activates CANCER
KDM3A activates Cancer
KDM3A activates Carcinoma

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