gene 916 words KG: HEXA
Contents

HEXA Gene - Hexosaminidase Alpha

🧬 Gene Info
Gene SymbolHEXA
AliasesPage for HEXA Gene
Chromosome15q24.1
FunctionThe HEXA gene encodes the alpha subunit of the enzyme β-hexosaminidase A (Hex A), a lysosomal hydrolase essential for the catabolism of GM2 ganglioside and other glycoconjugates containing N-acetylhex
Primary Expressionmost tissues with highest levels in:
UniProt IDP06865
NCBI Gene ID3073
Ensembl IDENSG00000213626
OMIM272800
GeneCardsHEXA
Human Protein AtlasHEXA
Associated Diseasesdisease
InteractionsDEMENTIA, GBA, NEURON, PARKINSON, PARKINSON'S DISEASE, Rb
KG Connections33 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Related Hypotheses (32)

CYP46A1 Overexpression Gene Therapy
Score: 0.98
AMPK hypersensitivity in astrocytes creates enhanced mitocho
Score: 0.82
Epigenetic Memory Erasure via TET2 Activation
Score: 0.74
PARP1 Inhibition Therapy
Score: 0.74
Senescence-Associated Myelin Lipid Remodeling
Score: 0.73
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.73
Magnetosonic-Triggered Transferrin Receptor Clustering
Score: 0.72
Circadian-Synchronized LRP1 Pathway Activation
Score: 0.71
Noradrenergic-Tau Propagation Blockade
Score: 0.71
Autophagosome Maturation Checkpoint Control
Score: 0.71
Microglial Efferocytosis Enhancement via GPR32 Superagonists
Score: 0.70
Complement C1q Mimetic Decoy Therapy
Score: 0.69
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
CX43 hemichannel engineering enables size-selective mitochon
Score: 0.69
Flotillin-1 Stabilization Compounds
Score: 0.68
Oligodendrocyte Protectin D1 Mimetic for Myelin Resolution
Score: 0.68
GAP43-mediated tunneling nanotube stabilization enhances neu
Score: 0.67
Mitochondrial RNA Granule Rescue Pathway
Score: 0.66
HCN1-Mediated Resonance Frequency Stabilization Therapy
Score: 0.65
Mitochondrial SPM Synthesis Platform Engineering
Score: 0.65
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Related Analyses (18)

Synaptic pruning by microglia in early AD
neurodegeneration · archived
Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived

Related Experiments (12)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40
Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propag
clinical · proposed · Score: 0.40
Neural Oscillation Dysfunction Validation in Parkinson's Dis
clinical · proposed · Score: 0.40

See Also (7)

Amyotrophic Lateral Sclerosis
redirect · KG edge: contributes_to
GBA (Redirect)
redirect · KG edge: associated_with
c9orf72-als-ftd-phenotype-mechanism
general · KG edge: contributes_to
Genes
index · KG edge: associated_with
HEXB Gene - Hexosaminidase Beta
gene · KG edge: associated_with

Knowledge Graph (12 edges)

HEXA contributes_to C9ORF72
GBA inhibits HEXA
HEXA co_discussed HEXB
HEXA associated_with HEXB
HEXA associated_with GBA
GBA associated_with HEXA
HEXB associated_with HEXA
HEXA inhibits Rb
HEXA contributes_to AMYOTROPHIC LATERAL SCLEROSIS
HEXA contributes_to HUNTINGTON

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