gene 2,335 words KG: EBF3
Contents

EBF3 — Early B-cell Factor 3

🧬 Gene Info
Gene SymbolEBF3
Full NameEarly B-cell Factor 3
Primary Expressionmature neurons, where it contributes to synaptic plasticity and cognitive function[@coe2019][@ebf2020]
Molecular Weight65 kDa
PathwaysDna Methylation, Epigenetic
Ensembl IDENSG00000108001
GeneCardsEBF3
Human Protein AtlasEBF3
Direct DNA BindingBinds to specific palindromic sequences in target gene promoters and enhancers
Chromatin RemodelingRecruits chromatin-modifying enzymes to open or close chromatin
Transcriptional Activation/RepressionCan both activate and repress target genes depending on context
Protein Complex FormationForms homodimers and heterodimers with other COE proteins
Associated DiseasesAlzheimer's disease, Parkinson's disease
KG Connections30 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (24)

Chromatin Accessibility Restoration via BRD4 Modulation
Score: 0.77
Senescent Cell Mitochondrial DNA Release
Score: 0.74
Near-infrared light therapy stimulates COX4-dependent mitoch
Score: 0.74
Epigenetic Memory Erasure via TET2 Activation
Score: 0.74
Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.73
TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.73
Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.73
TET2-Mediated Demethylation Rejuvenation Therapy
Score: 0.71
Perforant Path Presynaptic Terminal Protection Strategy
Score: 0.70
Mitochondrial Transfer Pathway Enhancement
Score: 0.70
CX43 hemichannel engineering enables size-selective mitochon
Score: 0.69
RAB27A-dependent extracellular vesicle engineering for mitoc
Score: 0.67
Partial Neuronal Reprogramming via Modified Yamanaka Cocktai
Score: 0.67
GAP43-mediated tunneling nanotube stabilization enhances neu
Score: 0.67
Temporal TET2-Mediated Hydroxymethylation Cycling
Score: 0.66
Mitochondrial RNA Granule Rescue Pathway
Score: 0.66
Arginine Methylation Enhancement Therapy
Score: 0.65
KDM6A-Mediated H3K27me3 Rejuvenation
Score: 0.65
DNMT1-Targeting Antisense Oligonucleotide Reset
Score: 0.65
Mitochondrial SPM Synthesis Platform Engineering
Score: 0.65
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Related Analyses (7)

Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived
Synaptic pruning by microglia in early AD
neurodegeneration · completed
Synaptic pruning by microglia in early AD
neurodegeneration · archived

Related Experiments (1)

Cytochrome Therapeutics
clinical · proposed · Score: 0.40

See Also (12)

Neurodegeneration
disease · KG edge: implicated_in
DNA Methylation
entity · KG edge: regulates
DNA Damage Repair Deficiency Validation Study in Parkin
experiment · KG edge: regulates
Epigenetic Clocks in Neurodegeneration — Causal Drivers
experiment · KG edge: regulates
Genes
index · KG edge: regulates

Knowledge Graph (12 edges)

CDK4 regulates EBF3
RB1 associated_with EBF3
EBF3 regulates MYC
EBF3 regulates TP53
EBF3 regulates MDM2
EBF3 regulates GBM
MDM2 regulates EBF3
TP53 regulates EBF3
EBF3 associated_with RB1
MYC regulates EBF3

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