gene 2,016 words KG: CASP2
Contents

CASP2 Gene

🧬 Gene Info
Gene SymbolCASP2
Full NameCaspase 2 (CASP2)
Chromosome7q34
Protein TypeProtein
FunctionCaspase 2 has diverse cellular functions beyond apoptosis:
Molecular Weight20 kDa
Amino Acids165 aa
PathwaysCell Cycle, Dna Repair, Oxidative Stress
UniProt IDSearch UniProt
Ensembl IDENSG00000106144
GeneCardsCASP2
Human Protein AtlasCASP2
Apoptosis initiationCASP2 is one of the initiator caspases that can trigger the intrinsic (mitochondrial) apoptotic pathway
Cell cycle regulationInvolved in G2/M checkpoint control
DNA damage responseActivated in response to genotoxic stress
Associated DiseasesAging, Cancer, Inflammation, Neurodegeneration
InteractionsAPOPTOSIS, AUTOPHAGY, UBIQUITIN
KG Connections36 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (6)

CYP46A1 Overexpression Gene Therapy
Score: 0.95
PARP1 Inhibition Therapy
Score: 0.74
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Cross-Seeding Prevention Strategy
Score: 0.69
Glycine-Rich Domain Competitive Inhibition
Score: 0.64
Cryptic Exon Silencing Restoration
Score: 0.53

Related Analyses (4)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (7)

Apoptosis in Neurodegeneration
entity · KG edge: activates
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: activates
DNA Damage Repair Deficiency Validation Study in Parkin
experiment · KG edge: causes
casp3
gene · KG edge: associated_with
Packard Center for ALS Research
institution · KG edge: activates

Knowledge Graph (12 edges)

CASP2 encodes CASPASE2
CASP2 participates_in TUMOR_SUPPRESSION
DIMERIZATION activates CASP2
CASP2 regulates PROTEOLYTIC_PROCESSING
CASP2 associated_with CASP3
CASP2 interacts_with UBIQUITIN
CASP2 binds_to UBIQUITIN
CASP2 regulates ubiquitin homeostasis
CASP2 modulates TARDBP
CASP2 participates_in APOPTOSIS

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