| Gene Symbol | AQP4 |
| Chromosome | 18q11.2 |
| Protein Family | Aquaporin (AQP) family |
| Target Class | Ion Channel |
| Mechanism of Action | Water channel inhibitor or modulator |
| Primary Expression | Astrocytes (perivascular endfeet), Ependyma, Kidney collecting duct |
| Subcellular Localization | Astrocyte end-feet, perivascular, ependymal |
| Druggability | Low (0.35) |
| Clinical Stage | Phase I |
| Molecular Weight | 34 kDa |
| Amino Acids | 323 aa |
| Pathways | Adaptive Immunity, Apoptosis, Blood-Brain Barrier, Chaperone, Glymphatic Pathway |
| UniProt ID | P55064 |
| Ensembl ID | ENSG00000171885 |
| GeneCards | AQP4 |
| Human Protein Atlas | AQP4 |
| Associated Diseases | AD, Aging, ALI, alpha-synuclein accumulation, Als |
| Known Drugs/Compounds | Astragaloside IV, dasatinib, MELATONIN, quercetin, riluzole, TGN-020 |
| Interactions | 4R-tau, ABCA1, ALPHA-SYNUCLEIN, ALS, ALZHEIMER, ALZHEIMER'S DISEASE |
| SciDEX Target | View Target Profile (1 clinical trials) |
| SciDEX Hypotheses | SASP-Driven Aquaporin-4 Dysregulation Aquaporin-4 Polarization Rescue CSF/Plasma AQP4 Polarization Index as a Novel Biom (+8 more) |
| KG Connections | 1784 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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