gene 1,995 words KG: ANT2
Contents

ANT2 (Adenine Nucleotide Translocator 2)

🧬 Gene Info
Gene SymbolANT2
Full NameAdenine Nucleotide Translocator 2 (ANT2)
AliasesSLC25A5
ChromosomeXq26.3
Functionis a mitochondrial inner membrane protein that catalyzes the exchange of ADP and ATP across the inner mitochondrial membrane.
Primary Expressionmost tissues, including the brain
Molecular Weight33 kDa
Amino Acids322 aa
UniProt IDP02724
NCBI Gene ID291
Ensembl IDENSG00000148218
OMIM300120
GeneCardsANT2
Human Protein AtlasANT2
Associated DiseasesChronic Kidney Disease, Nonalcoholic Fatty Liver Disease, Obesity
InteractionsGENES, HIF, INFLAMMATION, MTOR, TFEB
KG Connections21 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

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Related Hypotheses (3)

APOE-Dependent Autophagy Restoration
Score: 0.88
The Mitochondrial-Lysosomal Metabolic Coupling Dysfunction
Score: 0.65
TFEB-PGC1α Mitochondrial-Lysosomal Decoupling
Score: 0.62

Related Analyses (4)

Mechanistic role of APOE in neurodegeneration
neurodegeneration · archived
Gene expression changes in aging mouse brain predicting neur
neurodegeneration · completed
Metabolic reprogramming in neurodegenerative disease
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (12)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40
Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propag
clinical · proposed · Score: 0.40
Neural Oscillation Dysfunction Validation in Parkinson's Dis
clinical · proposed · Score: 0.40

See Also (6)

Neurodegeneration
disease · KG edge: implicated_in
TFEB (Redirect)
redirect · KG edge: activates
mTOR Signaling Dysregulation in Progressive Supranuclea
event · KG edge: activates
Genes
index · KG edge: activates
MTOR Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

ANT2 activates MTOR
ANT2 activates TFEB
TFEB activates ANT2
ANT2 associated_with Nonalcoholic Fatty Liver Disease
ANT2 activates INFLAMMATION
ANT2 activates Hepatitis
ANT2 activates Ms
ANT2 activates Inflammation
ANT2 activates Mtor
ANT2 activates HIF

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