| Gene Symbol | GAN |
| Full Name | Gigaxonin |
| Chromosome | 16q24.2 |
| Function | is a key component of the ubiquitin-proteasome system, functioning as a substrate adaptor for the Cullin-3 (CUL3)-RING ligase complex |
| Molecular Weight | 65 kDa |
| Amino Acids | 597 aa |
| Exons | 11 |
| Pathways | Blood-Brain Barrier, Immune Response, Nf-Κb, Tgf-Β, blood-brain barrier |
| UniProt ID | [Q9Y2H5](https://www.uniprot.org/uniprot/Q9Y2H5) |
| Ensembl ID | ENSG00000150433 |
| OMIM | 605379 |
| GeneCards | GAN |
| Human Protein Atlas | GAN |
| N-terminal BTB domain | Mediates homodimerization and interactions with Cullin-3 E3 ubiquitin ligases[@geyer2012] |
| Central BACK domain | Involved in substrate recognition |
| Associated Diseases | Giant Axonal Neuropathy |
| Interactions | AND, NEURODEGENERATION, NEURODEGENERATIVE DISEASES, NEURODEGENERATIVE DISORDERS, NF-ΚB, SYNUCLEINOPATHY |
| KG Connections | 54 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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