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mechanism 3,210 words KG: MAPK/ERK
Contents

MAPK/ERK Signaling Pathway in Neurodegeneration

⚙ Mechanism Info
NameMAPK/ERK
Key Genes/ProteinsAKT, BDNF, EGR1, ERBB2, ERK, integrins
Related Pathwaysautophagy, PI3K/AKT

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Related Hypotheses (1)

TYROBP Network Hyperactivation Marks Point of No Return
Score: 0.46

Knowledge Graph (12 edges)

autophagy activates MAPK/ERK
MAPK/ERK activates EGR1
SQSTM1/p62 inhibits MAPK/ERK
MAPK/ERK promotes neurodegeneration
integrins activates MAPK/ERK
reduced loading inhibits MAPK/ERK
ERK activates MAPK/ERK
MAPK activates MAPK/ERK
AUTOPHAGY activates MAPK/ERK
AKT inhibits MAPK/ERK

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