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disease 1,344 words KG: ent-dise-408ea38b
Contents

TREM2 Variants in Alzheimer's Disease

Disease Info
PhagocytosisClears Aβ plaques, cellular debris
SurvivalPromotes microglial survival
ProliferationSupports microglial expansion
Cytokine productionRegulates inflammatory responses
Lipid metabolismProcesses lipids and lipoproteins
DatabasesOMIMOrphanetClinicalTrialsPubMed

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OMIMMeSHWikipedia

Related Hypotheses (36)

Gamma entrainment therapy to restore hippocampal-cortical sy
Score: 0.90ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro
Score: 0.87Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82Prefrontal sensory gating circuit restoration via PV interne
Score: 0.78Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75APOE Isoform Expression Across Glial Subtypes
Score: 0.74SIRT3-Mediated Mitochondrial Deacetylation Failure with PINK
Score: 0.74Complement C1QA Spatial Gradient in Cortical Layers
Score: 0.68Excitatory Neuron Vulnerability via SLC17A7 Downregulation
Score: 0.67Astrocyte MCT1/MCT4 Ratio Disruption with Metabolic Uncoupli
Score: 0.67TREM2-mediated microglial tau clearance enhancement
Score: 0.62LRP1-Dependent Tau Uptake Disruption
Score: 0.60VCP-Mediated Autophagy Enhancement
Score: 0.59Extracellular Vesicle Biogenesis Modulation
Score: 0.58Synaptic Vesicle Tau Capture Inhibition
Score: 0.58HSP90-Tau Disaggregation Complex Enhancement
Score: 0.57Trans-Synaptic Adhesion Molecule Modulation
Score: 0.54APOE-TREM2 Interaction Modulation
Score: 0.74TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69
pg 1/2Next →

Related Analyses (27)

Astrocyte Reactivity Subtypes in Neurodegeneration
neurodegeneration · archivedImmune atlas neuroinflammation analysis in neurodegeneration
Neuroinflammation · completedNeuroinflammation and microglial priming in early AD
neurodegeneration · completedWhat are the optimal timing windows for TREM2 agonism vs ant
neurodegeneration · archivedDoes SYK activation provide neuroprotection or exacerbate ne
neurodegeneration · archived

Related Experiments (30)

TREM2 Function in Alzheimer's Disease — From Risk Variant to
validation · proposed · Score: 0.45Microglial TREM2 Agonist In Vivo Efficacy
validation · proposed · Score: 0.45TREM2 Agonist Therapy for Parkinson's Disease — Experimental
validation · proposed · Score: 0.45TREM2 KO amyloid pathology study
validation · completed · Score: 0.80TREM2 KO amyloid pathology study
validation · completed · Score: 0.80

See Also (15)

ASL Perfusion Biomarkers for Alzheimer's Disease
biomarker · Pages share 18 hypothesesDigital Biomarkers for Alzheimer's Disease
biomarker · Pages share 18 hypothesesDried Blood Spot Biomarker Test for Alzheimer's Disease
biomarker · Pages share 18 hypothesesDTI Biomarkers for Alzheimer's Disease
biomarker · Pages share 18 hypothesesEEG Biomarkers for Alzheimer's Disease
biomarker · Pages share 18 hypotheses

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