| Depression | Each point increase on depression scales correlates with a **-3.7 point decrease** in QoL scores (Morales-Rivero et al., 2025) |
| Apathy | Present in up to 70% of patients, severely impacting daily functioning |
| Anxiety | Contributes to reduced wellbeing and increased caregiver stress |
| Pseudobulbar affect | Involuntary emotional expressions affecting social interactions |
| PSP-QoL Scale | Both short and long versions validated for longitudinal use (Shen et al., 2025) |
| HRQoL measures | Health-related QoL instruments adapted for PSP populations |
| Non-motor symptom scales | Including the NMSQ adapted for PSP |
| PDQ-39 | Parkinson's Disease Questionnaire adapted for PSP |
| PSP-SI | PSP disability Index for functional assessment |
| Databases | OMIMOrphanetClinicalTrialsPubMed |
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