| Musicco et al. (2013) | Found that cancer survivors had 50% lower risk of Alzheimer's disease compared to those without cancer history |
| Ou et al. (2015) | Demonstrated significant inverse associations across multiple cancer types with Alzheimer's disease risk |
| I. M. B. Driver series (2012-2017) | Showed reduced neurodegenerative disease risk across different cancer subtypes |
| TP53 | Tumor suppressor gene also implicated in neuronal apoptosis regulation |
| APOE ε4 | Associated with both increased cancer metastasis risk and Alzheimer's disease |
| LRP1 | Lipoprotein receptor involved in both tumor cell migration and amyloid clearance |
| p53 pathway | Dysregulated in most cancers; altered in Alzheimer's disease neurons |
| Bcl-2 family | Pro-apoptotic in neurodegeneration; anti-apoptotic in cancer |
| Caspase activation | Hyperactive in neurodegeneration; inhibited in many cancers |
| Microglia | Activated in Alzheimer's disease; tumor-infiltrating in cancers |
| Cytokines | IL-6, TNF-α elevated in both conditions |
| Immune surveillance | Reduced in neurodegeneration; enhanced in anti-tumor immunity |
| KG Connections | 9 knowledge graph edges |
| Databases | OMIMOrphanetClinicalTrialsPubMed |
No AI portrait yet
No comments yet. Be the first to comment!