Contents

Alzheimer's Disease

Disease Info

Amyloid-beta plaques	Extracellular deposits of Aβ peptides (Aβ40, Aβ42)
Neurofibrillary tangles	Intracellular tau protein aggregates (paired helical filaments)
Neuronal loss	Progressive death of synapses and neurons, particularly in hippocampus and cortex
Neuroinflammation	chronic activation of microglia and astrocytes; the NF-κB Signaling pathway regulates this response
Synaptic dysfunction	Early loss of synaptic markers and function
Databases	OMIM Orphanet ClinicalTrials PubMed

No AI portrait yet

Knowledge Graph