Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CGAS/STING1/DNASE2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | CGAS/STING1/DNASE2 |
| Key Genes/Proteins | AQP4, C1Q/C3, CD38, CD38/NAMPT, CGAS, GPX4 |
| Related Diseases | neurodegeneration |
| Related Pathways | ferroptosis |
graph TD
CGAS_STING1_DNASE2[CGAS/STING1/DNASE2]
CGAS_STING1_DNASE2 -->|debate_co_mention| ferroptosis[ferroptosis]
CGAS_STING1_DNASE2 -->|debate_co_mention| GPX4[GPX4]
CGAS_STING1_DNASE2 -->|debate_co_mention| GPX4_SLC7A11[GPX4/SLC7A11]
CGAS_STING1_DNASE2 -->|debate_co_mention| IL1B[IL1B]
CGAS_STING1_DNASE2 -->|co_associated_with| MMP2_MMP9[MMP2/MMP9]
CGAS_STING1_DNASE2 -->|co_associated_with| PLA2G6_PLA2G4A[PLA2G6/PLA2G4A]
CGAS_STING1_DNASE2 -->|data_in| benchmark_ot_ad_answer_key_CGA[benchmark_ot_ad_answer_key:CGAS/STING1/DNASE2]
C1Q_C3[C1Q/C3] -->|debate_co_mention| CGAS_STING1_DNASE2
CD38[CD38] -->|debate_co_mention| CGAS_STING1_DNASE2
CD38_NAMPT[CD38/NAMPT] -->|debate_co_mention| CGAS_STING1_DNASE2
CGAS[CGAS] -->|debate_co_mention| CGAS_STING1_DNASE2
AQP4[AQP4] -->|co_associated_with| CGAS_STING1_DNASE2
benchmark_ot_ad_answer_key_CGA -->|data_in| CGAS_STING1_DNASE2| Target | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:CGAS/STING1/DNASE2 | data_in | dataset_row | 0.00 |
| neurodegeneration | associated_with | disease | 0.50 |
| ferroptosis | debate_co_mention | pathway | 0.45 |
| GPX4 | debate_co_mention | gene | 0.45 |
| GPX4/SLC7A11 | debate_co_mention | gene | 0.45 |
| IL1B | debate_co_mention | gene | 0.45 |
| MMP2/MMP9 | co_associated_with | gene | 0.40 |
| GPX4/SLC7A11 | co_associated_with | gene | 0.40 |
| PLA2G6/PLA2G4A | co_associated_with | gene | 0.40 |
| Source | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:CGAS/STING1/DNASE2 | data_in | dataset_row | 0.00 |
| C1Q/C3 | debate_co_mention | gene | 0.45 |
| CD38 | debate_co_mention | gene | 0.45 |
| CD38/NAMPT | debate_co_mention | gene | 0.45 |
| CGAS | debate_co_mention | gene | 0.45 |
| C1Q/C3 | co_associated_with | gene | 0.40 |
| AQP4 | co_associated_with | gene | 0.40 |
| CD38/NAMPT | co_associated_with | gene | 0.40 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Senescent Cell Mitochondrial DNA Release | 0.742 | neurodegeneration | Senolytic therapy for age-related neurod |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-01 | 8 hypotheses Top: 0.984
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| iPSC-derived astrocyte-neuron co-culture mitochondrial transfer in PD | exploratory | Parkinson's disease | 0.900 | 0.00 | iPSC-derived dopaminergic neur | proposed | N/A |
| Proposed experiment from debate on Senolytics targeting p16/p21+ senes | falsification | Neurodegeneration | 0.400 | 0.50 | cell_line | proposed | $80,000 |
| Biomechanical Impact Profiles and Chronic Traumatic Encephalopathy Phe | clinical | Neurodegeneration | 0.400 | 0.50 | in_silico | proposed | $180,000 |
| Sporadic ALS Initiation Biology: Deep Phenotyping of At-Risk Cohorts | clinical | ALS | 0.400 | 0.50 | human | proposed | $6,550,000 |
| cGAS-STING Pathway Validation Study in Parkinson's Disease | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $7,100,000 |
| Mixed Pathology Effects on Parkinson's Disease Progression and Treatme | clinical | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| NLRP3 Inflammasome Validation Study in Parkinson's Disease | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Regulated Necrosis Validation Study in Parkinson's Disease | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $6,550,000 |
| Senolytic Therapy (D+Q) Phase IIa Trial in Early Alzheimer's Disease | clinical | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Traumatic Brain Injury and Alzheimer's Disease Relationship | validation | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $3,000,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS [PMID:33031745] | Yu CH, Davidson S, Harapas CR, Hilton JB | Cell | 2020 | 2 |
| Past, present and future perspectives on the science of aging. [PMID:41566049] | Fabrisia Ambrosio; Maxim N Artyomov; Ste | Nature aging | 2026 | 0 |
| Stimuli-responsive nanoplatforms for precision activation of the STING pathway i [PMID:41668757] | ["Bi D", "Yang X", "Wang Y", "Yong J", " | Frontiers in immunology | 2026 | 0 |
| Decoding senescent drivers in Alzheimer's disease: From bench to bedside. [PMID:41344577] | ["Zhou R", "Lin X", "Liao Z", "Lin J", " | Ageing research reviews | 2026 | 0 |
| Role of NEIL1 in genome maintenance. [PMID:40010204] | ["McCullough A", "Minko I", "Luzadder M" | DNA repair | 2025 | 0 |
| Bionanoconjugates in Neurodegeneration: Peptide-Nanoparticle Alliances for Next- [PMID:41199078] | ["Ranjitha V", "Kumar A", "Kaalappa P"] | Pharmaceutical research | 2025 | 0 |
| Mitochondrial DNA released by senescent tumor cells enhances PMN-MDSC-driven imm [PMID:40203808] | ["Lai P", "Liu L", "Bancaro N", "Troiani | Immunity | 2025 | 0 |
| Apheresis for senescence: Targeting the senescence-associated secretory phenotyp [PMID:40651559] | ["Akgun Y"] | Ageing research reviews | 2025 | 0 |
| Methodological influences on circulating cell-free-mitochondrial and nuclear DNA [PMID:40080226] | ["Daubermann C", "Herhaus B", "Neuberger | Molecular biology reports | 2025 | 0 |
| Innate immune sensing of Z-nucleic acids by ZBP1-RIPK1 axis drives neuroinflamma [PMID:40902587] | ["Song Z", "Xie X", "Chen Y", "Zhang B", | Immunity | 2025 | 0 |
| Exosomes as nanocarriers for brain-targeted delivery of therapeutic nucleic acid [PMID:40533746] | ["Sanadgol N", "Abedi M", "Hashemzaei M" | Journal of nanobiotechnology | 2025 | 0 |
| Antileukemic potential of methylated indolequinone MAC681 through immunogenic ne [PMID:38704604] | ["Orlikova-Boyer B", "Lorant A", "Gajula | Biomarker research | 2024 | 0 |
| Enhancing Radiofrequency Ablation for Hepatocellular Carcinoma: Nano-Epidrug Eff [PMID:39548919] | ["Li X", "Liu Y", "Ke J", "Wang Z", "Han | Advanced materials (Deerfield | 2024 | 0 |
| The cGAS-STING pathway drives neuroinflammation and neurodegeneration via cellul [PMID:39490400] | Zhang Y, Zou M, Wu H, Zhu J, Jin T | Neurobiology of disease | 2024 | 0 |
| mtDNA release promotes cGAS-STING activation and accelerated aging of postmitoti [PMID:39039044] | ["Li Y", "Cui J", "Liu L", "Hambright W" | Cell death & disease | 2024 | 0 |
| Senescent glia link mitochondrial dysfunction and lipid accumulation. [PMID:38839958] | ["Byrns C", "Perlegos A", "Miller K", "J | Nature | 2024 | 0 |
| Apoptotic stress causes mtDNA release during senescence and drives the SASP. [PMID:37821702] | ["Victorelli S", "Salmonowicz H", "Chapm | Nature | 2023 | 0 |
| Exposome and unhealthy aging: environmental drivers from air pollution to occupa [PMID:37688657] | Pandics T, Major D, Fazekas-Pongor V, Sz | GeroScience | 2023 | 0 |
| cGAS-STING drives ageing-related inflammation and neurodegeneration. [PMID:37532932] | Gulen MF, Samson N, Keller A, Schwabenla | Nature | 2023 | 0 |
| Molecular mechanisms of mitochondrial DNA release and activation of the cGAS-STI [PMID:36964253] | ["Kim J", "Kim H", "Chung J"] | Experimental & molecular medic | 2023 | 0 |
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.40 · 2026-04-27
closed · Rounds: 4 · Score: 0.89 · 2026-04-06
Hypotheses and analyses mentioning CGAS/STING1/DNASE2 in their description or question text
No additional research found