Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PLA2G6/PLA2G4A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | PLA2G6/PLA2G4A |
| Key Genes/Proteins | AQP4, C1Q/C3, CD38/NAMPT, CGAS/STING1/DNASE2, GPX4, GPX4/SLC7A11 |
| Related Diseases | neurodegeneration |
| Related Pathways | mitophagy |
graph TD
PLA2G6_PLA2G4A[PLA2G6/PLA2G4A]
PLA2G6_PLA2G4A -->|debate_co_mention| SLC7A11[SLC7A11]
PLA2G6_PLA2G4A -->|debate_co_mention| STING1[STING1]
PLA2G6_PLA2G4A -->|debate_co_mention| senescence[senescence]
PLA2G6_PLA2G4A -->|data_in| benchmark_ot_ad_answer_key_PLA[benchmark_ot_ad_answer_key:PLA2G6/PLA2G4A]
GPX4[GPX4] -->|debate_co_mention| PLA2G6_PLA2G4A
MMP2_MMP9[MMP2/MMP9] -->|debate_co_mention| PLA2G6_PLA2G4A
NAMPT[NAMPT] -->|debate_co_mention| PLA2G6_PLA2G4A
MMP9[MMP9] -->|debate_co_mention| PLA2G6_PLA2G4A
neuroinflammation[neuroinflammation] -->|debate_co_mention| PLA2G6_PLA2G4A
PLA2G6[PLA2G6] -->|debate_co_mention| PLA2G6_PLA2G4A
mitophagy[mitophagy] -->|debate_co_mention| PLA2G6_PLA2G4A
AQP4[AQP4] -->|co_associated_with| PLA2G6_PLA2G4A
C1Q_C3[C1Q/C3] -->|co_associated_with| PLA2G6_PLA2G4A
CGAS_STING1_DNASE2[CGAS/STING1/DNASE2] -->|co_associated_with| PLA2G6_PLA2G4A| Target | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:PLA2G6/PLA2G4A | data_in | dataset_row | 0.00 |
| neurodegeneration | associated_with | disease | 0.50 |
| senescence | debate_co_mention | process | 0.45 |
| SLC7A11 | debate_co_mention | gene | 0.45 |
| STING1 | debate_co_mention | gene | 0.45 |
| Source | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:PLA2G6/PLA2G4A | data_in | dataset_row | 0.00 |
| MMP2/MMP9 | debate_co_mention | gene | 0.45 |
| NAMPT | debate_co_mention | gene | 0.45 |
| MMP9 | debate_co_mention | gene | 0.45 |
| neuroinflammation | debate_co_mention | process | 0.45 |
| GPX4 | debate_co_mention | gene | 0.45 |
| PLA2G6 | debate_co_mention | gene | 0.45 |
| mitophagy | debate_co_mention | pathway | 0.45 |
| AQP4 | co_associated_with | gene | 0.40 |
| C1Q/C3 | co_associated_with | gene | 0.40 |
| CGAS/STING1/DNASE2 | co_associated_with | gene | 0.40 |
| MMP2/MMP9 | co_associated_with | gene | 0.40 |
| CD38/NAMPT | co_associated_with | gene | 0.40 |
| GPX4/SLC7A11 | co_associated_with | gene | 0.40 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Senescence-Associated Myelin Lipid Remodeling | 0.732 | neurodegeneration | Senolytic therapy for age-related neurod |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-01 | 8 hypotheses Top: 0.910
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Proposed experiment from debate on Senolytics targeting p16/p21+ senes | falsification | Neurodegeneration | 0.400 | 0.50 | cell_line | proposed | $80,000 |
| Proposed experiment from debate on Microglia activate astrocytes via I | falsification | Neuroinflammation | 0.400 | 0.50 | cell_line | proposed | $80,000 |
| Iron Dyshomeostasis in MSA Pathogenesis Experiment | validation | Neurodegeneration | 0.400 | 0.50 | human | proposed | $2,280,000 |
| Oligodendrocyte-Myelin Dysfunction Validation in Parkinson's Disease | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $7,100,000 |
| Senolytic Therapy (D+Q) Phase IIa Trial in Early Alzheimer's Disease | clinical | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Copy number deletion of PLA2G4A affects the susceptibility and clinical phenotyp [PMID:38816399] | Gao Z, Guo X, Sun Z, Wu S, Wang Q, Huang | Schizophrenia (Heidelb) | 2024 | 1 |
| Lipoprotein-associated and secreted phospholipases A₂ in cardiovascular disease: [PMID:21098459] | Mallat Z, Lambeau G, Tedgui A | Circulation | 2010 | 1 |
| Phospholipase A2 regulation of bovine endometrial (BEND) cell prostaglandin prod [PMID:18811942] | Godkin JD, Roberts MP, Elgayyar M, Guan | Reprod Biol Endocrinol | 2008 | 1 |
| Arachidonic acid analog AACOCF3 suppresses cPLA2-negative NSCLC cell proliferati [PMID:41544858] | Wang H, Wen Z, Jia Y, Tong X, Wang W et | Biochem Pharmacol | 2026 | 0 |
| Modification of the dermal matrix by senescence associated lipids and its functi [PMID:41690117] | ["Jelleschitz S", "Kremslehner C", "Nage | Redox biology | 2026 | 0 |
| White matter lipid alterations during aging in the rhesus monkey brain. [PMID:39312153] | ["Dimovasili C", "Vitantonio A", "Conner | GeroScience | 2025 | 0 |
| Rejuvenation Modulation of Nucleus Pulposus Progenitor Cells Reverses Senescence [PMID:39969420] | ["Zhao D", "Zhang J", "Chen C", "Sun W", | Advanced materials (Deerfield | 2025 | 0 |
| Correction of dysregulated lipid metabolism normalizes gene expression in oligod [PMID:40216746] | ["Rezaei A", "Kocsis-Jutka V", "Gunes Z" | Nature communications | 2025 | 0 |
| Ferroptosis as a potential molecular mechanism of bipolar disorder. [PMID:40537482] | ["Yehia A", "Melhuish Beaupre L", "Ho M" | Translational psychiatry | 2025 | 0 |
| Microglia activation orchestrates CXCL10-mediated CD8+ T cell recruitment to pro [PMID:40404995] | Groh J, Feng R, Yuan X, Liu L, Klein D, | Nature neuroscience | 2025 | 0 |
| Nose-to-Brain Delivery of Circular RNA SCMH1-Loaded Lipid Nanoparticles for Isch [PMID:40143778] | ["Jia Y", "Xu L", "Leng S", "Sun Y", "Hu | Advanced materials (Deerfield | 2025 | 0 |
| Exosomes as nanocarriers for brain-targeted delivery of therapeutic nucleic acid [PMID:40533746] | ["Sanadgol N", "Abedi M", "Hashemzaei M" | Journal of nanobiotechnology | 2025 | 0 |
| Oligodendroglial fatty acid metabolism as a central nervous system energy reserv [PMID:39251890] | ["Asadollahi E", "Trevisiol A", "Saab A" | Nature neuroscience | 2024 | 0 |
| Association between PLA2 gene polymorphisms and treatment response to antipsycho [PMID:37290257] | Nadalin S, Zatković L, Peitl V, Karlović | Prostaglandins, leukotrienes, | 2023 | 0 |
| Ferroptosis of Microglia in Aging Human White Matter Injury. [PMID:37605362] | Adeniyi PA, Gong X, MacGregor E, Degener | Annals of neurology | 2023 | 0 |
| Differences in the post-stroke innate immune response between young and old. [PMID:37045990] | ["Gallizioli M", "Arbaizar-Rovirosa M", | Seminars in immunopathology | 2023 | 0 |
| Contactin 1, a Potential New Antigen Target in Membranous Nephropathy: A Case Re [PMID:34762973] | ["Santoro D", "Debiec H", "Longhitano E" | American journal of kidney dis | 2022 | 0 |
| Cellular Senescence in Brain Aging. [PMID:33732142] | ["Sikora E", "Bielak-Zmijewska A", "Dudk | Frontiers in aging neuroscienc | 2021 | 0 |
| White matter aging drives microglial diversity. [PMID:33606969] | Safaiyan S, Besson-Girard S, Kaya T, Can | Neuron | 2021 | 0 |
| Towards microstructure-informed material models for human brain tissue. [PMID:31887455] | ["Budday S", "Sarem M", "Starck L", "Som | Acta biomaterialia | 2020 | 0 |
Multi-agent debates referencing this entity
Hypotheses and analyses mentioning PLA2G6/PLA2G4A in their description or question text
No additional research found