concept

C3AR

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about C3AR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

16Connections

3Hypotheses

0Analyses

9Outgoing

7Incoming

1Experiments

0Debates

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💡 Concept Info

Name	C3AR
Key Genes/Proteins	BETA_CATENIN, C3, C3A, GSK3B
Related Diseases	DENDRITIC_MORPHOLOGY

Wiki Pages (1)

Knowledge base pages for this entity

C3AR1 Gene

gene · 870 words

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Pathway Diagram

graph TD
    C3AR["C3AR"]
    C3AR -->|"modulates"| Neuronal_Apoptosis["Neuronal Apoptosis"]
    C3AR -->|"downregulates"| __catenin_Signaling["beta-catenin Signaling"]
    C3AR -->|"inhibits"| DENDRITIC_MORPHOLOGY["DENDRITIC_MORPHOLOGY"]
    C3AR -->|"activates"| MICROGLIA["MICROGLIA"]
    C3AR -->|"regulates"| BETA_CATENIN["BETA_CATENIN"]
    C3AR -->|"activates"| GSK3B["GSK3B"]
    C3["C3"] -->|"binds"| C3AR
    C3A["C3A"] -->|"binds"| C3AR
    Complement_C3["Complement C3"] -->|"interacts"| C3AR
    SB290157["SB290157"] -->|"inhibits"| C3AR

Outgoing (9)

Target	Relation	Type	Str
ASTROCYTES	mediates	cell_type	0.85
MICROGLIA	mediates	cell_type	0.85
NEURON	mediates	cell_type	0.85
ASTROCYTE	interacts_with	cell_type	0.80
DENDRITIC_MORPHOLOGY	inhibits	phenotype	0.64
MICROGLIA	activates	cell_type	0.64
cognitive impairment	associated_with	disease	0.60
BETA_CATENIN	regulates	protein	0.56
GSK3B	activates	protein	0.56

Incoming (7)

Source	Relation	Type	Str
C3A	activates	protein	0.90
C3	activates	protein	0.90
C3	interacts_with	protein	0.87
Complement C3	interacts_with	protein	0.80
C3A	interacts_with	protein	0.72
C3	activates	protein	0.72
SB290157	inhibits	drug	0.72

Targeting Hypotheses (3)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Astrocyte C3aR Signaling as Bifurcation Point for A1/A2 Fate	0.750	Alzheimer's disease, Parkinson's disease	-
C3aR Blockade Disrupts the Microglial-Astrocyte Feedforward	0.633	neuroinflammation	What molecular mechanisms determine whet
Complement Cascade Specificity: Microglial C3aR Antagonism D	0.618	synaptic biology	Does SPP1-mediated synaptic engulfment r

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (1)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
iPSC-derived astrocyte-neuron co-culture mitochondrial transfer in PD	exploratory	Parkinson's disease	0.900	0.00	iPSC-derived dopaminergic neur	proposed	N/A

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning C3AR in their description or question text

No additional research found