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cell 1,440 words KG: microglia
Contents

Microglia in Batten Disease

🧫 Cell Type Info
Cell Typemicroglia
Associated DiseasesAlzheimer's disease, cardiovascular diseases, neurodegeneration, neuroinflammation, stroke
Related GenesALS, BDNF, C3, CD33, ent-gene-28e2cb01
Linked Hypotheses636 hypotheses

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Wikipedia

Related Hypotheses (45)

TREM2-APOE microglial state switching across AD, ALS, and PD
Score: 0.80TREM2-mediated microglial tau clearance enhancement
Score: 0.78Mutant-dependent amplification is context-dependent and stro
Score: 0.74TREM2 haploinsufficiency dysregulates microglial synaptic su
Score: 0.70Rab27A/B-mediated exosomal tau secretion from microglia driv
Score: 0.69TREM2 R47H variant synergizes with APOE4 to collapse microgl
Score: 0.68LPS-primed microglial trained immunity establishes persisten
Score: 0.67Gamma entrainment enhances TREM2-mediated microglial clearan
Score: 0.65Calibrated PLCG2 activation can reproduce the protective rs7
Score: 0.65Anti-inflammatory microglial reprogramming via cystatin-C/TR
Score: 0.64APOE4-microglial complement signaling causes cholinergic-enr
Score: 0.63C1q has spatially distinct functions, with synapse-bound C1q
Score: 0.63APOE ε4-driven microglial lipid handling as proximal driver
Score: 0.63sex-divergent microglial activation states and X-linked immu
Score: 0.63Tau fibrils expose neuronal phosphatidylserine and heat-shoc
Score: 0.62TREM2-mediated microglial tau clearance enhancement
Score: 0.62Female microglia exhibit heightened complement gene expressi
Score: 0.61microglial priming as a partially upstream causal node rathe
Score: 0.60TREM2 enhancement as a way to restore protective microglial
Score: 0.60Intermittent HBOT (2.0 ATA, 60 min, 3x/week) suppresses NLRP
Score: 0.59
pg 1/3Next →

Related Analyses (10)

TREM2 Therapeutic Strategy Post-INVOKE-2
neurodegeneration · completedGBA-Synuclein Loop Therapeutics for PD
neurodegeneration · completedGut-Brain Axis Therapeutics for AD
neurodegeneration · completedTREM2 agonism vs antagonism in DAM microglia
neurodegeneration · completedAstrocyte reactivity subtypes in neurodegeneration
neurodegeneration · completed

Knowledge Graph (12 edges)

VCP associated_with microglia
mBDNF associated_with microglia
microglia associated_with BDNF
EGFR expresses microglia
GRN associated_with microglia
BIN1 associated_with microglia
CLU associated_with microglia
GFP associated_with microglia
ABCA1 associated_with microglia
GDNF associated_with microglia

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