| Gene Symbol | ATG12 |
| Aliases | ATG12PROTEIN |
| Chromosome | 5q21.2 |
| Protein Family | ATG12 family |
| Function | is a ubiquitin-like protein that plays an essential role in autophagy, the cellular process for degrading and recycling damaged organelles and proteins. |
| Subcellular Localization | Cytoplasm, autophagosome membrane |
| Molecular Weight | ~15 kDa |
| Pathways | Autophagy, Cell Cycle, Mitophagy |
| UniProt ID | O95166 |
| NCBI Gene ID | 9459 |
| Ensembl ID | ENSG00000181458 |
| GeneCards | ATG12 |
| Human Protein Atlas | ATG12 |
| Mitophagy | the ATG12–ATG5 complex is required for PINK1/Parkin-mediated mitophagy of damaged mitochondria[@lazarou2015] |
| Aggrephagy | selective degradation of protein aggregates, requiring ATG12-dependent LC3 lipidation for p62-mediated aggregate recognition |
| Associated Diseases | Als, Alzheimer, Ataxia, Infection, Ms, Neurodegeneration |
| Known Drugs/Compounds | rapamycin |
| Interactions | ACTB, AGING, AKT, ALS, ALZHEIMER, AMPK |
| KG Connections | 459 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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