concept

ATAD3A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ATAD3A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

33Connections

0Hypotheses

0Analyses

26Outgoing

7Incoming

0Experiments

0Debates

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💡 Concept Info

Name	ATAD3A
Key Genes/Proteins	APP, CYP46A1, P62
Related Diseases	Alzheimer'S Disease, Cerebral ischemia-reperfusion injury, Cholesterol Accumulation
Related Pathways	autophagy pathway, Cholesterol Metabolism, lipid metabolism, mitophagy

Pathway Diagram

graph TD
    ATAD3A[ATAD3A]
    ATAD3A -->|provides_data_for| ds_db4a006ea647[ds-db4a006ea647]
    ATAD3A -.prevents.-> PD_L1_mitochondrial_distributi[PD-L1 mitochondrial distribution]
    ATAD3A -->|regulates| Cholesterol_Metabolism[Cholesterol Metabolism]
    ATAD3A -->|contributes to| Alzheimer_S_Disease[Alzheimer'S Disease]
    ATAD3A -->|inhibits| PINK1[PINK1]
    ATAD3A -->|promotes| triple_negative_breast_cancer_[triple-negative breast cancer resistance to ICI plus paclitaxel]
    ATAD3A -->|inhibits| CYP46A1[CYP46A1]
    ATAD3A -->|promotes| Cholesterol_Accumulation[Cholesterol Accumulation]
    ATAD3A -->|inhibits| mitophagy[mitophagy]
    ds_db4a006ea647 -->|data_in| ATAD3A
    TRIM25[TRIM25] -->|modifies| ATAD3A
    paclitaxel[paclitaxel] -->|upregulates| ATAD3A
    DA1[DA1] -->|targets| ATAD3A
    APP[APP] -->|activates| ATAD3A
    benchmark_ot_ad_answer_key_ATA[benchmark_ot_ad_answer_key:ATAD3A] -->|data_in| ATAD3A

Outgoing (26)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:ATAD3A	data_in	dataset_row	0.00
ds-db4a006ea647	provides_data_for	dataset	1.00
Alzheimer'S Disease	contributes_to	disease	0.95
Cholesterol Metabolism	regulates	pathway	0.95
PD-L1 mitochondrial distribution	prevents	process	0.95
mitophagy	inhibits	pathway	0.90
PINK1	inhibits	protein	0.90
triple-negative breast cancer resistance to ICI plus paclitaxel	promotes	phenotype	0.90
CYP46A1	inhibits	gene	0.90
Cholesterol Accumulation	promotes	phenotype	0.90
Alzheimer'S Disease	therapeutic_target	disease	0.90
Synaptic Loss	promotes	phenotype	0.85
App Processing	promotes	process	0.85
Cerebral ischemia-reperfusion injury	exacerbates	disease	0.80
PINK1	activates	gene	0.60
TRIM25	activates	gene	0.60
P62	expressed_in	gene	0.60
PINK1	expressed_in	gene	0.60
CYP46A1	activates	gene	0.60
TRIM25	regulates	gene	0.60
TRIM25	interacts_with	gene	0.60
lipid metabolism	participates_in	pathway	0.60
TRIM25	expressed_in	gene	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
autophagy pathway	participates_in	pathway	0.60
neurons	expressed_in	cell_type	0.55

Incoming (7)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:ATAD3A	data_in	dataset_row	0.00
ds-db4a006ea647	data_in	dataset	1.00
TRIM25	associated_with	protein	0.95
paclitaxel	upregulates	drug	0.85
DA1	targets	drug	0.85
APP	activates	gene	0.60
APP	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ATAD3A in their description or question text

No additional research found