Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about ACETYLATION: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | ACETYLATION |
graph TD
ACETYLATION["ACETYLATION"]
ACETYLATION -->|"regulates"| Autophagy["Autophagy"]
ACETYLATION -->|"regulates"| PEPCK["PEPCK"]
ACETYLATION -->|"modulates"| ULK1["ULK1"]
ACETYLATION -->|"modulates"| BECN1["BECN1"]
ACETYLATION -->|"modulates"| PIK3C3["PIK3C3"]
ACETYLATION -->|"regulates"| LC3_Lipidation["LC3 Lipidation"]
ACETYLATION -->|"modulates"| ULK1_Complex["ULK1 Complex"]
ACETYLATION -->|"regulates"| LC3_Lipidation_System["LC3 Lipidation System"]
PEPCK -->|"modulates"| ACETYLATION
TFAM["TFAM"] -->|"modulates"| ACETYLATION| Target | Relation | Type | Str |
|---|---|---|---|
| Autophagy | regulates | process | 0.95 |
| PEPCK | regulates | enzyme | 0.95 |
| Pck1 Activity | regulates | mechanism | 0.95 |
| MAP1LC3 | modulates | protein | 0.95 |
| PIK3C3 | modulates | protein | 0.90 |
| ULK1 | modulates | protein | 0.90 |
| BECN1 | modulates | protein | 0.90 |
| LC3 Lipidation | regulates | process | 0.90 |
| Anaplerotic Reactions | modulates | pathway | 0.85 |
| Gluconeogenesis | modulates | pathway | 0.85 |
| gluconeogenesis | regulates | pathway | 0.85 |
| anaplerotic reactions | regulates | pathway | 0.85 |
| STX17 | modulates | protein | 0.85 |
| ULK1 Complex | modulates | protein | 0.85 |
| LC3 Lipidation System | regulates | process | 0.85 |
| TFEB | modulates | protein | 0.85 |
| SQSTM1 | modulates | protein | 0.80 |
| autophagosome formation | regulates | process | 0.80 |
| TFEB | regulates | protein | 0.80 |
| TFAM | inhibits | protein | 0.75 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| SIRT3-Mediated Mitochondrial Deacetylation Failure with PINK | 0.738 | Alzheimer's Disease | Cell type vulnerability in Alzheimers Di |
| HDAC6 Selective Inhibition to Restore Acetylation Balance an | 0.643 | structural biology | What is the atomic-resolution structure |
| SIRT3 loss creates a mitochondrial acetylation-stress loop t | 0.560 | neurodegeneration | What mechanisms drive the self-amplifyin |
| N-acetylation Deficiency as Novel Metabolic Vulnerabilities | 0.540 | neurodegeneration | Gap 006 analysis (archived stub) |
| HDAC1/2 Complex Restoration Corrects Age-Related Histone Hyp | 0.520 | neurodegeneration | Investigate mechanisms of epigenetic rep |
| SIRT3 gates microglial surveillance versus primed metabolism | 0.482 | neuroinflammation | Do microglia actually switch between gly |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| iPSC-derived astrocyte-neuron co-culture mitochondrial transfer in PD | exploratory | Parkinson's disease | 0.900 | 0.00 | iPSC-derived dopaminergic neur | proposed | N/A |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Transcriptomic cytoarchitecture reveals principles of human neocortex organizati [PMID:37824655] | Jorstad NL, Close J, Johansen N, Yanny A | Science | 2023 | 186 |
| Targeted nanovesicular delivery of dexmedetomidine modulates microglial lysosoma [PMID:41778730] | Zhang Y, Jiang H, Zhang F, Liao J | Neural regeneration research | 2026 | 0 |
| The myocardial ischemic cascade network and multi-target synergistic interventio [PMID:41544859] | Qi L, Yi J, Shen Y, Jiang H, Yao X et al | Biochem Pharmacol | 2026 | 0 |
| Homoplantaginin ameliorates osteoarthritis by activating Sirt3/PINK1/Parkin sign [PMID:41720004] | Zhang H, Xiao J, Yi Y, Chen B, Lv W et a | Phytomedicine | 2026 | 0 |
| Kakkalide promotes spinal cord injury repair by regulating microglial M2 polariz [PMID:41720005] | You T, Dai B, Ding X, He Z, Peng J et al | Phytomedicine | 2026 | 0 |
| Interaction of mtROS-Immune-Inflammatory Vicious Cycle Activation in Sepsis-Indu [PMID:41905969] | Wang Y, Yuan Q | Clin Exp Pharmacol Physiol | 2026 | 0 |
| Metformin attenuates HSV-1-induced neuropathic pain by restoring Sirt3-mediated [PMID:41896899] | Yuanyuan Fang; Mengqiu Deng; Kesheng Hua | Cell communication and signali | 2026 | 0 |
| Hydrogen-Enriched Hyaluronic Acid Dressing Ameliorates Diabetic Foot Ulcer via P [PMID:41906653] | Xu Z, Cui X, Chu H, Wan H, Xie Y, Wang Y | Journal of diabetes | 2026 | 0 |
| Inhibition of mitochondrial ROS turns LC3-associated phagocytosis to autophagy u [PMID:41896101] | Cheng YL, Su MS, Liao CC, Chang TW, Hsie | Journal of microbiology, immun | 2026 | 0 |
| Hyperoside stabilizes ACAT1 to promote fatty acid oxidation and attenuate kidney [PMID:41903436] | Shan C, Szili-Torok T, Yue G, Zhang L, M | Phytomedicine : international | 2026 | 0 |
| Melatonin Ameliorates decaBDE-Induced Autism-Relevant Behaviors Through Promotin [PMID:41897550] | ["Gao L", "Shen J", "Gao J", "Li T", "Ya | Antioxidants (Basel, Switzerla | 2026 | 0 |
| Sirtuins as mediators and targets of arsenic toxicity: unraveling signaling path [PMID:40844627] | El-Mahrouk SR, El-Kadi AOS | Archives of toxicology | 2025 | 0 |
| Targeted activation of ErbB4 receptor ameliorates neuronal deficits and neuroinf [PMID:40089796] | Liu C, Zhao Y, Zhang W, Dao JJ, Li Q, Hu | Journal of neuroinflammation | 2025 | 0 |
| Phenylpropanoids of Eleutherococcus senticosus (Rupr. & maxim.) maxim. Alleviate [PMID:40081261] | Yang R, Meng X, Zhao W, Xu SQ, Wang SY, | Bioorganic chemistry | 2025 | 0 |
| Small molecule DDQ involvement of ERK-mediated signaling pathway with enhanced m [PMID:40222458] | Pradeepkiran JA, Kshirsagar S, Alvir RV, | Biochimica et biophysica acta. | 2025 | 0 |
| The effects of Honokiol on the liver of Alzheimer's disease mice by upregulating [PMID:40776632] | Wang H, Liu J, Tian YR, Zhu F, Li H | Journal of Alzheimer's disease | 2025 | 0 |
| Publisher Correction: Age and sex affect deep learning prediction of cardiometab [PMID:33414494] | Gerrits, Elen, Van Craenendonck, Trianta | Scientific Reports | 2021 | 0 |
| The human olfactory system in two proteinopathies: Alzheimer's and Parkinson's d [PMID:32493457] | Ubeda-Bañon I, Saiz-Sanchez D, Flores-Cu | Translational neurodegeneratio | 2020 | 0 |
| Diagnostic delays in Middle East respiratory syndrome coronavirus patients and h [PMID:31006635] | Ahmed AE | Journal of infection and publi | 2019 | 0 |
| Homeostatic Control of Hpo/MST Kinase Activity through Autophosphorylation-Depen [PMID:29262338] | Zheng Y, Liu B, Wang L, Lei H, Pulgar Pr | Cell reports | 2017 | 0 |
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning ACETYLATION in their description or question text