Contents

IGF2R Protein

🔬 Protein Info

Gene Symbol	IGF2R
Protein Family	Mannose-6-phosphate receptor family
Protein Type	Receptor
Target Class	Receptor
Function	is a protein encoded by the IGF2R gene.
Mechanism of Action	Drugs targeting IGF2R typically work by blocking IGF2 binding and signaling through the IGF1R/IGF2R axis, thereby inhibiting mitogenic and anti-apoptotic effects in cancer cells. Alternatively, agents may enhance IGF2 clearance through IGF2R-mediated endocytosis to reduce circulating IGF2 levels and downstream signaling.
Primary Expression	neurons, astrocytes, and oligodendrocytes, where it participates in the regulation of IGF2 signaling and
Subcellular Localization	Cell membrane, endosomes, lysosomes
Druggability	Low (0.39)
Clinical Stage	Approved
Molecular Weight	274 kDa
Amino Acids	147 aa
Pathways	Lysosomal Enzyme Trafficking, Lysosomal function / degradation, Normal Growth and Development
UniProt ID	A0N9R6
GeneCards	IGF2R
Human Protein Atlas	IGF2R
Associated Diseases	Aging, Als, Alzheimer, Alzheimer's disease, Amyotrophic Lateral Sclerosis
Known Drugs/Compounds	Linsitinib (OSI-906), Figitumumab (CP-751,871), Ganitumab (AMG 479), MK-0646 (Dalotuzumab)
Interactions	AGING, ALS, ALZHEIMER, ALZHEIMER'S DISEASE, AMYOTROPHIC LATERAL SCLEROSIS, AND
SciDEX Target	View Target Profile (2 clinical trials)
SciDEX Hypotheses	Lysosomal Enzyme Trafficking Correction
KG Connections	307 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

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