Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about ...: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| neurodegeneration | implicates_in | disease | 0.68 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| ... | 0.680 | neurodegeneration | Gene expression changes in aging mouse b |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-02 | 0 hypotheses
neurodegeneration | 2026-04-02 | 1 hypotheses Top: 0.680
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2- [PMID:31932797] | Zhou Y, Song WM, Andhey PS, Swain A, Lev | Nat Med | 2020 | 1 |
| Repurposing of doxycycline as a novel therapeutic avenue for management of parki [PMID:41925933] | Ali NH, Al-Kuraishy HM, Hussain NR, Al-G | Inflammopharmacology | 2026 | 0 |
| Histological findings in follow-up liver biopsies up to 15 years after pediatric [PMID:41370831] | Quintero-Bernabeu J, Salcedo-Allende MT, | Liver Transpl | 2026 | 0 |
| Knee Osteoarthritis as a Causal Risk Factor for Parkinson's Disease: Converging [PMID:41925436] | Peng Z, Wang G | The American journal of geriat | 2026 | 0 |
| Reactive astrocyte subpopulations with high Gfap and C4b expression in different [PMID:41837502] | Huang C, Han Y, He J, Ma W, Chen Y, Dong | Neural regeneration research | 2026 | 0 |
| Longitudinal investigation of the T helper (Th)1-Th2 balance and complement syst [PMID:41872173] | Zhang T, Zhao J, Tang X, Wei Y, Ju M, Zh | Translational psychiatry | 2026 | 0 |
| Global C3 lowering in adulthood protects against hippocampal dysfunction and cog [PMID:40678242] | ["Batista A", "Presumey J", "Singh B", " | Research square | 2025 | 0 |
| Diverse cell types establish a pathogenic immune environment in peripheral neuro [PMID:40410792] | ["Choi J", "Strickland A", "Loo H", "Don | Journal of neuroinflammation | 2025 | 0 |
| Alzheimer's disease clinical variants show distinct neuroinflammatory profiles w [PMID:39400356] | ["Boon B", "Frigerio I", "de Gooijer D", | Neuropathology and applied neu | 2024 | 0 |
| TREM2 receptor protects against complement-mediated synaptic loss by binding to [PMID:37442133] | Zhong L, Sheng X, Wang W, Li Y, Zhuo R, | Immunity | 2023 | 0 |
| [WALANT - Wide Awake Local Anaesthesia No Tourniquet: Complications in elective [PMID:35168268] | Wieschollek S, Forster S, Megerle K | Handchirurgie, Mikrochirurgie, | 2022 | 0 |
| Loss of microglial SIRPα promotes synaptic pruning in preclinical models of neur [PMID:33795678] | Ding X, Wang J, Huang M, Chen Z, Liu J, | Nature communications | 2021 | 0 |
| Adaptive learning algorithms to optimize mobile applications for behavioral heal [PMID:33657217] | Figueroa CA, Aguilera A, Chakraborty B, | Journal of the American Medica | 2021 | 0 |
| Engineering complex communities by directed evolution. [PMID:33986540] | Chang CY, Vila JCC, Bender M, Li R, Mank | Nature ecology & evolution | 2021 | 0 |
| A Novel N-terminal Region to Chromodomain in CHD7 is Required for the Efficient [PMID:34161779] | Lee E, Kang C, Purhonen P, Hebert H, Bou | Journal of molecular biology | 2021 | 0 |
| A distributional code for value in dopamine-based reinforcement learning. [PMID:31942076] | Dabney W, Kurth-Nelson Z, Uchida N, Star | Nature | 2020 | 0 |
| Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2- [PMID:31932797] | Zhou Y, Song WM, Andhey PS, Swain A, Lev | Nat Med | 2020 | 0 |
| PDK1 Mediates NOTCH1-Mutated Head and Neck Squamous Carcinoma Vulnerability to T [PMID:30770351] | Sambandam V, Frederick MJ, Shen L, Tong | Clinical cancer research : an | 2019 | 0 |
| TREM2 triggers microglial density and age-related neuronal loss. [PMID:30548312] | Linnartz-Gerlach B, Bodea LG, Klaus C, G | Glia | 2019 | 0 |
| Human hepatocyte transplantation for liver disease: current status and future pe [PMID:29149103] | Iansante V, Mitry RR, Filippi C, Fitzpat | Pediatric research | 2018 | 0 |
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.95 · 2026-04-02
closed · Rounds: 4 · Score: 0.56 · 2026-04-02
Hypotheses and analyses mentioning ... in their description or question text
No additional research found