disease 1,534 words KG: ent-dise-3cb3a8d4
Contents

Schizophrenia

Disease Info
HallucinationsMost commonly auditory (hearing voices), but can involve any sensory modality
DelusionsFixed false beliefs resistant to contradictory evidence (paranoid, grandiose, somatic, religious)
Disorganized thinkingFormal thought disorder manifested as tangential, incoherent, or illogical thought processes
Bizarre behaviorInappropriate or unpredictable actions, catatonia in severe cases
Affective flatteningReduced emotional expression and reactivity
AlogiaReduced speech output and poverty of speech
AvolitionLack of motivation and reduced goal-directed activity
AnhedoniaInability to experience pleasure
Social withdrawalReduced interest in social interactions
Working memory impairmentInability to hold and manipulate information
Attention deficitsDifficulty sustaining focus and filtering irrelevant stimuli
Executive dysfunctionProblems with planning, reasoning, and cognitive flexibility
KG Connections2 knowledge graph edges
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Related Hypotheses (16)

Gamma entrainment therapy to restore hippocampal-cortical sy
Score: 0.90
Prefrontal sensory gating circuit restoration via PV interne
Score: 0.78
Complement C1q Mimetic Decoy Therapy
Score: 0.69
...
Score: 0.68
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
Tau-Independent Microtubule Stabilization via MAP6 Enhanceme
Score: 0.57
Senescence-Associated Myelin Lipid Remodeling
Score: 0.73
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
APOE-TREM2 Interaction Modulation
Score: 0.74
TREM2 Conformational Stabilizers for Synaptic Discrimination
Score: 0.69
Complement C1QA Spatial Gradient in Cortical Layers
Score: 0.68
HCN1-Mediated Resonance Frequency Stabilization Therapy
Score: 0.65
TREM2-mediated microglial tau clearance enhancement
Score: 0.62
TREM2-Mediated Selective Aggregate Clearance Pathway
Score: 0.58
TREM2-Dependent Microglial Senescence Transition
Score: 0.58

Related Analyses (7)

Synaptic pruning by microglia in early AD
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Metabolic reprogramming in neurodegenerative disease
neurodegeneration · completed
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived

Related Experiments (5)

Reproductive fitness analysis of psychiatric disorders in Sw
clinical · proposed · Score: 0.95
Differential GWAS of schizophrenia vs PTSD
exploratory · proposed · Score: 0.90
Gestational haloperidol exposure effects on hippocampal gene
validation · proposed · Score: 0.90
Dual-luciferase assay for miR-137-3p target validation
exploratory · proposed · Score: 0.80
Synaptic plasticity and protein expression analysis in mPFC
exploratory · proposed · Score: 0.85

Knowledge Graph (2 edges)

29785013 have biologically distinct roles in ent-dise-3cb3a8d4
24210810 is a risk factor for ent-dise-3cb3a8d4

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